The San Francisco 49ers (3-0) host the Cleveland Browns (2-2) for a Week 5 clash on Monday Night Football from the Bay Area. Kickoff is set for 8:15 PM EST on October 6th at Levi’s Stadium and the game will be broadcast on ESPN.

Oddsmakers opened this game up with the 49ers listed as 3-point home favorites. That spread increased by half a point after early betting, as San Francisco is currently available at -3.5. The total for this matchup is 46.5 points. Click here for a full look at the Week 5 NFL odds and for more links to our individual game previews.

49ers vs Browns Game Odds & Betting Preview

Cleveland Browns

The Browns got back to .500 on the season last weekend after a very impressive 40-25 road victory over AFC North rival Baltimore. Cleveland jumped out to a 10-7 lead in the first half and never looked back, outscoring the Ravens 30-18 over the final two quarters en route to a critical double-digit divisional win. QB Baker Mayfield was 20/30 for 342 passing yards and one touchdown while RB Nick Chubb exploded for 165 yards and three touchdowns on the ground. WR Jarvis Landry also had a monster game, hauling in eight receptions for 167 yards. As a whole, the Browns offense racked up well over 500 total yards and scored five touchdowns against a shell-shocked Baltimore defense.

Cleveland also looked pretty good defensively in Week 4, holding the Ravens to just over 400 total yards of offense and three touchdowns. They also recorded two interceptions and didn’t allow a single rushing touchdown or even a single 75-yard performance on the ground.

San Francisco 49ers

The 49ers have still yet to lose a game this year, beating Pittsburgh 24-20 at home their last time out to move to 3-0 overall on the season. San Francisco trailed by a field goal after the first two quarters but found a way to escape with a victory after a three-touchdown performance in the second half. QB Jimmy Garoppolo looked average at best, going 23/32 for 277 yards and a touchdown but also getting picked off twice. Raheem Mostert and Matt Breida were a nice one-two punch on the ground, combining for 147 rushing yards on 26 total carries. TE George Kittle led the way for the receiving corps, making six catches for 57 yards. Overall, the 49ers generated almost 450 total yards of offense and scored three touchdowns.

San Francisco had a pretty decent showing defensively against Pittsburgh, holding the Steelers offense to just over 250 total yards and giving up only two touchdowns. The Niners were especially tough against the run, surrendering 79 net rushing yards on 22 attempts.

Free NFL Betting Predictions and Pick: 49ers -3.5

I think Cleveland might be a pretty trendy pick here in Week 5, as recency bias could be a factor after their extremely impressive road win against the Ravens last weekend. The 49ers also are coming off of their bye week, which could make the Browns even more popular considering how much air-time their upset win in Week 4 received over the past six or seven days. Even so, I think San Francisco currently offers the best value in this matchup, although I would likely stay away if this spread gets any larger. The 49ers have yet to lose a game so far this season, while Cleveland had only one win through their first three games.

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San Francisco has also been performing quite well against the spread as of late, going 4-1 ATS over their last five meetings against AFC opponents. They have really been impressive on Monday Night Football as well, going a rock-solid 12-2 ATS in their last 14 appearances. On the other side, the Browns are only 1-7 straight up over their last eight meetings with teams from the NFC West. Baker Mayfield has also been pretty inconsistent through his first four games, as it seems like he has been alternating between good and bad starts. The 49ers have only given up 18 points per game so far this season, so I’m not sure that Mayfield well have a ton of success in his second appearance on MNF this year. I’ll lay this small spread and roll with the home favorites – give me San Francisco to cover!