The San Francisco 49ers will chase their first win of the season this week when they visit the Indianapolis Colts. Game time is set for 1:00 EST on Sunday, October 8 at Lucas Oil Stadium in Indianapolis. Fans can watch the game in local markets on Fox.

The Colts are listed as 1.5-point home favorites. The over/under for the game is 46 points. Click here for a full list of the Week 5 betting odds and links to more game previews.

49ers vs Colts Game Preview & Betting Odds

It’s been a struggle for Kyle Shanahan, who is still searching his first win as a head coach. The aging Brian Hoyer has struggled to bring consistency to the San Francisco offense, and that has made things difficult on the usually reliable 49ers defense. 

To be fair, the 49ers have been close in most of their games. After a 20-point loss to the Panthers in Week 1, San Francisco’s last three losses have come by a combined eight points. The 49ers have enough talent to stay competitive with good teams, but so far they haven’t made enough plays to put them over the top late in games.

Meanwhile, the Colts continue to struggle without Andrew Luck. The franchise quarterback is getting closer to returning, but it’ll still be Jacoby Brissett who gets the start against San Francisco. In past years, the Colts have failed to give Luck enough support around him, and they are certainly paying the price now that Luck is unavailable coming off shoulder surgery.

However, there is a silver lining for the Colts. While just 1-3, every other team in their division is just 2-2. If Indy can steal a win without Luck, they’ll actually be in good shape when Luck is finally ready to return.

Free NFL Pick Against the Spread: Colts -1.5

It’s always tough to pick between two teams that have had trouble winning games. But the Colts at least have one win on the season. They’re also the home team in this matchup, so I’ll lean toward the Colts in a game that’s essentially a PK.

Last week’s game against the Seahawks got out of hand with a couple defensive touchdowns, but prior to that, Brissett made some progress. He played well against the Browns the previous week and even ran for two touchdowns, showing another part of his game. Yes, it was only against the Browns, but Brissett showed me enough the past two weeks to think that he can continue to get better each week. Plus, after facing Seattle’s defense, playing the 49ers won’t seem so difficult for him.

Click on the link for more free NFL betting predictions from our experts on staff.

Indy’s problems are primarily on the defensive side, but the 49ers aren’t necessarily the type of team that can expose that. Hoyer has just two touchdown passes on the season and is averaging only 5.8 yards per pass attempt and less than 200 yards per game. With only a modest running game, even the Indianapolis defense should have success against the San Francisco offense.

In fact, there’s only one game this season in which the 49ers have actually scored a touchdown. That was on a Thursday night against the Rams, and a couple of the touchdowns in that game came late when San Francisco was playing from behind. Even when the 49ers have managed to move the ball, they have struggled to finish drives in the end zone.

A team that can’t score touchdowns is almost never going to win on the road. Meanwhile, the Colts, despite some issues in the 4th quarter, have played much better at home early in the season. Within the friendly confines of Lucas Oil Stadium, Brissett will do enough to lead the Colts to their second win of the season.