The Washington Redskins (2-2) will host the San Francisco 49ers (0-5) this Sunday. Kickoff is set for 1:00 EST at FedEx Field and will be televised locally on FOX.

Oddsmakers currently have Washington listed as a 10-point home favorite with the total set at 46.5 points. Click here to check out our Week 6 NFL betting schedule, which includes links to our game previews.

49ers vs Redskins Vegas Betting Predictions & Game Odds

San Francisco comes into this game off 23-26 loss on the road against the Colts, where they failed to cover as a 1-point underdog. The 49ers are one of 3 teams without a win in 2017. On the bright side, they do have a winning record at 3-2 ATS.

The Redskins will be returning from their bye week, looking to rebound from a 20-29 loss to the Chiefs on Monday Night Football. Washington failed to cover as a 6.5-point dog, thanks to a bizarre ending, where they started throwing the ball around as time expired and KC picked it up and ran it in for TD.

This will be the first meeting between these two teams since the 2014 regular season, which the 49ers won 17-13 at home as a 9.5-point favorite.

NFL Betting Predictions & Free Pick Against the Spread: Redskins -10

I don’t love laying this many points in the NFL, but I just feel the situation here is too good to pass up. On one side you have a Washington team that is returning from their bye in a game they has to feel like a must win to keep pace in the NFC East. Especially with road games against the Eagles and Seahawks sandwiched around a home game against the Cowboys in their next three.

Click on the link for more free NFL picks from our expert handicappers on staff.

As for the 49ers, they have to be running on fumes right now. San Francisco is playing their 3rd straight road game and with each trip they have had to go further east, starting with Arizona, before going to Indy and now Washington. It doesn’t come up often, but rarely do teams play well in that 3rd game of a 3-game trip. Especially if it’s a poor team like the 49ers, who are clearly in rebuilding mode.

The fact that the Redskins weren’t expected to do much coming into the year and they are sitting at just 2-2, I don’t think the public will be running to back them here. I personally have really been impressed with this team. Their two losses are against arguably the two teams playing the best football early on in the Chiefs and Eagles. While they lost both by more than a touchdown, the final score doesn’t do justice to how well they played. In both games they fumbled and let the defense return it for a TD in the final two minutes.

The Washington defense has really caught my eye and they rank in the top half of the league against both the run (10th, 88.8 ypg) and pass (15th, 222.5 ypg). That unit should be able to slow down a weak 49ers offense that has scored 15 or less in 3 of their 5 games. San Francisco’s offense ranks 20th in both rushing and passing.

This is also not a good 49ers defense. San Francisco ranks in the bottom half of the league against both the run (19th, 116.6 ypg) and the pass (26th, 249.8 ypg). Keep in mind the schedule has been favorable to this point. The best offense they have faced is the Rams and they were torched for 41 points. Redskins rank 8th in total offense and should be well-prepared for what the 49ers like to do.

Redskins are 8-2 ATS in their last 10 games after allowing more than 250 yards passing in their previous game, 9-3 ATS in their last 12 vs a team with a losing record and a perfect 5-0 ATS after their last 5 games following a game where they didn’t cover.