The Arizona Cardinals (0-3-1) head to Ohio this weekend for a clash with the Cincinnati Bengals (0-4). Kickoff is set for 1:00 PM EST on October 6th at Paul Brown Stadium and the game will be broadcast on FOX.

Oddsmakers opened this game up with the Bengals listed as 4.5-point home favorites. That line has shifted by over a full point after early betting, as Cincinnati is currently available at -3. The total for this matchup is 47.5 points. Click here for a full look at the Week 5 NFL odds and for more links to our individual game previews.

Bengals vs Cardinals Game Odds & Betting Preview

Arizona Cardinals

The Cardinals lost their third game in a row last weekend, falling 27-10 at home against Seattle to drop to 0-3-1 on the season overall. Arizona trailed the Seahawks 20-3 in the first half and never recovered, scoring just seven points over the final two quarters en route to a disappointing divisional loss. QB Kyler Murray went 22/32 for 241 passing yards but couldn’t find the end zone through the air all game. Murray did score a touchdown on the ground despite only having four rushing attempts all game. RB David Johnson had a decent outing, racking up 139 total yards on 19 touches. Larry Fitzgerald led the way for the receiving corps despite only catching five passes for 47 yards. Overall, the Cardinals generated just under 350 total yards and only scored a single touchdown against one of their biggest NFC West rivals.

Arizona was slightly better on the defensive side of the ball in Week 4, giving up just over 350 total yards of offense and two touchdowns. The Cardinals managed to somewhat contain Seattle QB Russell Wilson, who passed for 240 yards and one touchdown but only gained seven yards on the ground all game.

Cincinnati Bengals

The Bengals have still not found a way to win their first game of the regular season, as they came up empty-handed yet again last week following a tough 27-3 home loss to Pittsburgh on Monday Night Football. Cincinnati was behind by just a seven points at the end of the second quarter before completely falling apart in the second half, getting outscored 17-0 by the Steelers. QB Andy Dalton certainly wasn’t at his best, going 21/37 for 171 yards and no touchdowns while also getting picked off once. Joe Mixon also struggled to get anything going out of the backfield, as he gained only 62 rushing yards on 15 carries. WR Auden Tate had a strong showing after John Ross was forced to leave the game due to injury, hauling in four catches for 50 yards. As a whole, the Bengals offense gained less than 250 total yards and failed to find the end zone against their biggest AFC North rival.

Cincinnati had a slightly below average performance on the defensive side of the ball in Week 4, giving up almost 350 total yards of offense and three touchdowns. The Bengals struggled to defend against the pass, as Steelers QB Mason threw for almost 250 yards and two touchdowns.

Free NFL Betting Predictions and Pick: Cardinals +3

I’m not really too crazy about either of these two winless teams against the spread here in Week 5, although I did think the Cardinals offered decent value when they opened at +4.5. However, now that Arizona is only getting a field goal in this matchup, there certainly isn’t as much value to be found. Even so, I don’t think I can lay any points with a Cincinnati squad that has only scored 37 points combined over their last three games. While the Bengals defense has been much better than they were during the 2018-19 regular season, they simply don’t have the same depth on offense now that both A.J. Green and John Ross are out. Even though Joe Mixon, Tyler Boyd, and perhaps even Auden Tate should be able to find some success against a terrible Arizona defense on Sunday afternoon, I still think that I want the points in a game that could go either way.

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The Bengals have also really struggled against the spread when playing at home as of late, going just 1-6 ATS over their last seven games. They are also a dreadful 0-6 straight up in their last six games overall. While the Cardinals certainly haven’t fared much better – they are just 0-7-1 straight up over their last eight games – they should be able to stay competitive throughout and could easily win outright. As long as the Cards are getting 3+ points, I’ll take a stab with the small road underdog. Give me Arizona to cover!