The San Francisco 49ers (2-8) head to Florida this weekend to battle the Tampa Bay Buccaneers (3-7). Kickoff is set for 1:00 PM EST on November 25th at Raymond James Stadium and the game will be broadcast on FOX.

Oddsmakers opened this game up with the Bucs listed as 4-point home favorites. That line has shifted by just half a point after early betting, as Tampa Bay is currently available at -3.5. The total for this matchup is 55 points. Click here for a full look at the Week 12 NFL odds and for more links to our individual game previews.

Buccaneers vs 49ers Vegas Odds & Game Preview

San Francisco lost 27-23 against the New York Giants back in Week 10, as they had a chance to get a bit of a rest last weekend during their bye. The 49ers have really struggled so far this season, coming into Week 12 with just a 2-8 record overall. It appears that QB Nick Mullens will make another start on Sunday after throwing for 512 yards and four touchdowns in his first two appearances against New York and Oakland. Mullens has had a ton of help from TE George Kittle, who has already racked up 775 receiving yards and three touchdowns this year. RB Matt Breida also is enjoying a breakout season, rushing for 5.6 yards per carry including a 101 yard performance against the Giants. Overall, San Francisco is currently averaging 23.0 points per game (18th overall) on 356.5 yards of total offense.

The 49ers haven’t looked that great on the other side of the ball through their first ten games, as opponents are currently averaging a healthy 26.6 points per game (27th overall) on 344.2 yards of total offense. However, San Francsico has been above average against the run for the most part, giving up just 102.2 yards per game on the ground (13th overall).

Tampa Bay lost their fourth consecutive game last weekend, falling 38-35 to the New York Giants in Week 11 to drop to 3-7 overall. The revolving door at quarterback continued, as Ryan Fitzpatrick was benched in the second half in favor of Jameis Winston after throwing three interceptions. It appears as if Winston will get the start here in Week 12, although there is certainly no guarantee he will finish the game after throwing 11 interceptions this season himself. RB Peyton Barber had a break-out game on the ground against New York, rushing for over 100 yards and finding the end zone for just the second time in ten games. WR Mike Evans also turned in a solid performance, racking up six catches for 120 yards and a touchdown. As a whole, Tampa Bay is currently averaging 26.7 points per game (8th overall) on 458.5 total yards of offense.

The Bucs have been a disaster defensively so far this season, getting torched for an average of 32.9 points per game. They have been especially bad against the pass, giving up 282.3 yards per game through the air (28th overall).

Free NFL Betting Prediction: Tampa Bay -3.5

While I was almost certain I’d take the 49ers in this contest pretty much all week long, I just don’t feel comfortable siding with a relatively unknown quarterback who threw two interceptions in his last start. The sample size simply isn’t there, I don’t care how terrible the Bucs have played defensively. It was also just announced that WR Marquise Wilson is listed as doubtful for Sunday due to personal reason. His absence will be a huge blow for a 49ers offense that already doesn’t have a ton of star-power, so I like Tampa Bay even more in this spot now. 

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San Francisco is just 1-6 ATS over their last seven games against an NFC opponent. They are also a brutal 0-5 ATS in their last five games following a bye and 3-7 ATS over their last ten games overall. Tampa Bay is a solid 4-2 ATS over their last six home games against the 49ers. Home field has been a big advantage in this particular matchup, as the visitors are only 3-7 ATS in the last ten meetings between these two teams.

Jameis Winston looked pretty good in relief of Fitzmagic last weekend, so I’m expecting him to be able to keep his momentum going this weekend against a San Francisco defense that just gave up three touchdowns to aging Eli Manning. The Bucs currently have the top passing offense in the entire NFL, averaging 361 passing yards per game. I’m going to take a stab with the home favorite and lay the 3.5 points – give me Tampa Bay.