This Sunday the Indianapolis Colts (0-1) will host the Arizona Cardinals (0-1) in a non-conference matchup between two teams looking to avoid the dreaded 0-2 start. Kickoff is set for 1:00 EST at Lucas Oil Stadium and will be televised locally on FOX.

Taking a look at the Week 2 betting lines, oddsmakers have the Cardinals listed as a 7-point road favorite. The over/under for this one is currently at 44 points.

Cardinals vs Colts Vegas Game Odds & Betting Preview

Arizona jumped out to a 10-0 lead and were up 17-9 in the 2nd half, but wound up losing 23-35 as a 2-point road favorite. Detroit scored 26 in about a 16 minute span from the 3rd and 4th quarter. The Cardinals suffered more than just a loss, star running back David Johnson injured his Wrist and is on IR.

It was even worse for the Colts in Week 1, as they got annihilated 46-9 by the Los Angeles Rams. Just about everything that could go wrong went wrong. The defense had no answer for Jared Goff and the Colts defense had two touchdowns and a safety. Most expected Indianapolis to be bad without Andrew Luck, but they went into that game as mere 3.5-point dog.

NFL Free Pick & Betting Predictions on the Total: OVER 44

Given how bad the Colts offense looked against a Rams defense that was missing their best player in Aaron Donald and Arizona losing what most consider the centerpiece of their offense, I don’t think there will be a lot of people rushing to be the OVER. That’s a good thing, as it creates value on the OVER with a low total for early in the season. Not to mention this being played in a dome, which seems to lead to higher scores.

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What people are overlooking with how bad the Colts offense performed, is the Rams had more points than this total on their own against them. Not having Johnson for an extended period will hurt Arizona’s chances of being a threat in the NFC. I don’t know that it will keep them from moving the ball against a bad Colts defense that is missing a lot of key pieces.

Their best corner, Vontae Davis is out indefinitely, while starting linebacker Antonio Morrison, starting nose tackle Al Woods and starting safety Darius Butler are all questionable. As is Morrison’s backup Anthony Walker Jr. Palmer may be old and rusty, but he’ll be able to do what he loves best and attack this defense down the field. That’s going to lead to big plays and quick scores.

Now for the Colts offense, it isn’t going to be good with Luck sidelined, but I also don’t think it will be as bad as it was on the road in Week 1. It will certainly benefit the OVER if Jacoby Brissett is able to take over for Scott Tolzien this week (I believe it’s just a matter of learning the playoff and given he’s from NE, I expect him to be ready). He at least gives them a fighting chance. This also isn’t the same caliber of Arizona defense as years past and even though it’s just Week 2, it’s never easy playing back-to-back road games in the NFL.

History is on our site as well. The OVER is 12-4 in the Cardinals 16 games as a road favorite under head coach Bruce Arians, as well as 6-0 in their last 6 road games after a turnover margin of -2 or worse. OVER is also 14-5 in the Colts last 19 under Pagano as a dog of 3.5 to 9.5 and 13-4 in their last 17 after allowing more than 300 passing yards in their previous game. Take the OVER!