The Arizona Cardinals (0-2-1) host the Seattle Seahawks (2-1) on Sunday for an important NFC West divisional matchup. Kickoff is set for 4:05 PM EST on September 29th at University of Phoenix Stadium and the game will be broadcast on FOX.

Oddsmakers opened this game up with the Cardinals listed as 4-point home underdogs. That line has shifted by a full point after early betting, as Arizona is currently available at +5. The total for this matchup is 48 points. Click here for a full look at the Week 4 NFL odds and for more links to our individual game previews.

Cardinals vs Seahawks Game Odds & Betting Preview

Seattle Seahawks

The Seahawks lost their first game of the season last weekend, falling 33-27 at home against New Orleans to drop to 2-1 overall. Seattle trailed 20-7 at the half and couldn’t pull off a dramatic comeback despite scoring 20 points in the 4th quarter. QB Russell Wilson was fantastic, going 32/50 for 406 passing yards and two touchdowns while also finding the end zone twice on the ground. Tyler Lockett also had a monster outing, exploding for 154 receiving yards and a touchdown on a game-high 11 receptions. As a whole, the Seahawks offense racked up well over 500 total yards of offense and scored four touchdowns despite coming up just short on the scoreboard.

Seattle wasn’t nearly as impressive on the other side of the ball in Week 3, allowing the Saints offense to gain more than 250 total yards and score three touchdowns. The Seahawks really had a tough time trying to slow down New Orleans RB Alvin Kamara, as he gained 161 total yards and scored two touchdowns in the victory.

Arizona Cardinals

The Cardinals have still not found a way to win their first game of the regular season, as they came up empty-handed yet again last weekend following a tough 38-20 home loss to Carolina. Arizona was behind by just four points at the end of the second quarter before completely falling apart in the second half, getting outscored 24-10 by the Panthers. QB Kyler Murray certainly wasn’t at his best, going 30/43 for 173 yards and two touchdowns but also getting picked off twice. However, he did have a solid day on the ground, rushing eight times for 69 yards. WR Christian Kirk led the way for the receiving corps, catching 10 passes for 59 yards. Overall, the Cardinals offense generated under 300 total yards and scored only two touchdowns against a pretty solid Carolina defense.

Arizona had yet another poor outing on the defensive side of the ball in Week 3, giving up well over 400 total yards of offense and five touchdowns. The Cardinals were especially weak defending against the pass, as Panthers QB Kyle Allen threw for almost 300 yards and found the end zone on four separate occasions.

Free NFL Betting Predictions and Pick: OVER 48

I was initial drawn to Seattle when they opened at -4 earlier in the week, but I am far less enthusiastic about that play against the spread now that the Seahawks are only available at -5. This divisional matchup could easily come down to a late field goal either way, and I wouldn’t even be surprised if Arizona won outright. However, I do think that the OVER on 48 total points scored still offers some decent value. The Cardinals have been one of the worst defensive teams in the league, which certainly bodes well for the Seattle offense in this particular spot. Wilson and Co. are coming off a 27-point outing against New Orleans in Week 3 and should have a ton of momentum heading into this NFC West battle.

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Arizona has also shown that they can put up some points in a hurry when necessary, scoring 27 at home against Detroit back in Week 1. The Seahawks are also a much weaker team on defense than they have been in recent years, giving up 79 points over their first three outings this season. It is also important to note that the OVER has now hit in six out of the last seven games that Seattle has played, and four out of the last six games that Arizona has been involved in. This matchup could easily end up having a scoreline that resembles something pretty close to 28-24, so I’m going to avoid both teams against the spread and take the OVER on 48 points instead.