The Buffalo Bills (0-1) will try and rebound this weekend against the Los Angeles Chargers (0-1) who are also looking for their first win of the season. Kickoff is set for 1:00 PM EST on Sunday, September 17th at New Era Field. The game will be televised on CBS.

Oddsmakers originally listed Los Angeles as 8-point road favorites. That line has moved a little bit, as the Chargers are currently available at -7.5. The total for this game is 44 points. Click here for a full look at the Week 2 NFL odds and for more links to our individual game previews.

Bills vs Chargers Vegas Odds & Game Preview

Buffalo was completely atrocious in Week 1, losing 47-3 on the road against the Baltimore Ravens. QB Nathan Peterman looks like one of the worst NFL quarterbacks in the history of the league, going 5/18 for just 24 yards. He also threw two interceptions, moving his career INT total to seven despite only playing in two games. It looks like the Bills will turn to rookie QB Josh Allen this weekend against Los Angeles. He will likely lean heavily on RB LeSean McCoy, who only had seven carries total last weekend. Allen looked like a significant improvement on Peterman (which isn’t saying much) after coming into the game in the second half in relief.

The Bills defense was almost as bad as their offense, as they allowed the Ravens to put up 47 points on almost 400 total yards. Baltimore is far from an offensive powerhouse, so things could get even worse for Buffalo this weekend against a high-octane Chargers attack. Playing at home in front of the “Bills Mafia” should certainly help a little bit, however, this certainly seems like a spot where Buffalo’s weak secondary is exposed yet again.

Los Angeles lost their home opener against the Kansas City Chiefs last weekend despite an impressive performance by QB Phillip Rivers and the rest of the Chargers offense. Rivers threw for over 400 yards while also adding three touchdowns, a performance he has a good chance of repeating this Sunday.  He should also have plenty of time to find open receivers downfield, as Buffalo only recorded two sacks in their first game. RB Melvin Gordon should also have a strong game, as he will likely receive plenty of touches in a game the Chargers are expected to lead throughout.

The Chargers defense was a definite weak-spot last weekend against the Chiefs, as Los Angeles surrendered 38 points after allowing Kansas City to rack up almost 400 total yards. Despite likely missing LB Joey Bosa for a second consecutive game on Sunday, things should be much easier for the Chargers D against a weak offensive line and a rookie quarterback starting his first NFL game.

Free NFL Betting Prediction: Chargers -7.5

I’m a bit surprised that the line has moved slightly in favor of Buffalo after Los Angeles originally opened at -8. I don’t expect this game to stay close at all and have a hard time envisioning a scenario where the Chargers don’t win by double digits. Yes, they are playing on the road but Rivers and Co. will be eager to avoid yet another 0-2 start on the season. It was an absolute massacre when these two teams met last season, as the Chargers put up 54 points and won by more than four touchdowns.

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Los Angeles has an extremely balanced attack that will have little difficulty scoring with ease against the Bills this weekend. Melvin Gordon just put up 166 yards from scrimmage, while Rivers put up video-game numbers against a significantly better defense than he will face on Sunday. WR Keenan Allen should also put up strong numbers yet again this weekend, as he is coming off an impressive 100+ yards receiving on eight receptions against KC.

The Bills are just 2-4 ATS over their past six games against the Chargers while Los Angeles is 9-4 ATS over their past 13 games, 5-2 ATS over their past seven road games, and 4-1 ATS over their past five after an ATS loss.

Although I do expect the Bills to look better this week – let’s be honest, they can’t really look much worse than they did against the Ravens – Josh Allen still needs time to develop as a starting quarterback. He won’t get much help from a defense that just gave up 47 points to an ageing Joe Flacco. Allen’s offensive line likely won’t offer him all that much time and space in the pocket either, so I don’t see how he pulls off a strong enough performance to keep Buffalo within reach. Los Angeles should be able to limit LeSean McCoy as well, especially since the Buffalo passing-game doesn’t really pose much of a threat. Laying the points seems like the smart play in this particular spot, as I think the Chargers should dominate on both sides of the ball en route to a lopsided road victory.