The San Diego Chargers are set to host the Denver Broncos on Thursday Night Football. These two AFC West rivals will kickoff Week 6 action at 8:25 EST at Qualcomm Stadium. The game will be televised on CBS. Oddsmakers have Denver as a 3-point favorite with the total set at 44.5 points.

Broncos vs Chargers Vegas Odds Preview

Denver (4-1) comes into this contest off a surprising 16-23 home loss to the Falcons. It snapped the Broncos perfect 4-0 start to the season. It also marked the first game they failed to cover the spread, as they were a 3-point favorite.

San Diego (1-4) suffered yet another heartbreaking loss. The Chargers fell 31-34 at Oakland. They had a chance to force overtime, but a botched snap on a field goal prevented that from happening. That’s now 4 losses on the season for San Diego, all of which have come by 6-points or less.

The Broncos have won each of the last 5 meetings in the series. Last year they won 17-3 at San Diego and 27-20 at home. The Chargers last win in the series was a 27-20 win at Denver back in 2013.

Free Pick & Betting Predictions: Chargers +3

This is a tough game to predict, but my early lean would have to be on the Chargers as a home dog. San Diego isn’t as bad as their 1-4 record would indicate. In fact, they are a few plays away from being 4-1 and even 5-0. I know it’s not easy backing teams that seem to find a way to lose, but the bad fortune of the Chargers can’t keep going.

You also have to take into consideration the line is begging for you to take Denver. I fully expect the betting public to do just that. Most consider the Broncos an elite team and will bank on them not losing 2 straight games.

Click here for more NFL betting advice on Week 6 games.

However, this isn’t a great spot for the Broncos. Head coach Gary Kubiak won’t be on the sidelines. Keep in mind he also serves as the play caller on offense and is one of the best at it in the NFL. There’s also a chance Denver might not have Trevor Siemian back at quarterback. Paxton Lynch wasn’t great in his first start. Regardless of who starts, the offense doesn’t figure to have the same rhythm to it without Kubiak.

San Diego’s defense also matches up well with the Broncos. Denver wants to establish the run and that’s the one thing the Chargers are good at stopping. San Diego hasn’t allowed a team to run for 100 yards on them this season. In fact, the most they have allowed is 93. Denver could also be without right tackle Donald Stephenson, which would be a big loss. Atlanta abused his backup last week.

I also think the Broncos might be a bit overrated right now. Yes, they are 4-1, but let’s look at who they have beat. Their 4 wins are against the Panthers, Colts, Bengals and Buccaneers. All of which will go into Week 6 with a losing record.

It’s also important to note that San Diego is going to show up for this game. While their chances of making the playoffs are slim at 1-4, they don’t like Denver. They would love nothing more than to put an end to their 5-game losing streak in the series.

Chargers are 21-9 ATS in their last 30 off a cover where they lost outright as an underdog. They are also a perfect 6-0 ATS in their last 6 off a loss to a division opponent.