This Sunday the San Diego Chargers will host the Kansas City Chiefs in a key AFC West matchup. Kickoff is set for 4:25 EST at Qualcomm Stadium and will be televised locally on CBS. Looking at the Week 17 odds, the Chiefs are a 4-point favorite with the total at 45 points.

Chiefs vs Chargers Vegas Odds Preview

Kansas City (11-4) comes in off an impressive 33-10 win at home over the Broncos. The victory kept the Chiefs hopes of an AFC West title and the No. 2 seed in the AFC alive. Kansas City had already clinched a playoff spot by the time they took on Denver. To win the division, the Chiefs need to beat the Chargers and have the Broncos take down the Raiders on Sunday.

San Diego (5-10) comes in off a 17-20 loss to the Browns. It was Cleveland’s first win of the season. The Chargers have now lost 4 straight and are just playing for pride at this point.

These two teams met back in Week 1 at Kansas City. San Diego led 24-3 in the 3rd quarter and 27-10 with less than 10 minutes to play. The Chiefs somehow managed to tie it up at 27-27 at the end of regulation. They would then go on to win 33-27 with a TD on the first possession of overtime. It was the largest comeback in 56 years by Kansas City.

Free Pick & Betting Predictions: Chiefs -4

With Kansas City’s win over Denver, the Chiefs have now won 10 straight division games. I’ll take my chances they make it 11 in a row and do enough to cover this spread. Kansas City is also now a ridiculous 21-4 over their last 25 regular season games.

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It’s clear the Chiefs are the only ones with something to play for in this game. With that said, I do think the Chargers are going to bring a better effort than they did against the Browns. I also think people are going to look at how well San Diego played against the Chiefs in the opener.

The thing is, these are two completely different teams from Week 1. The Chiefs are a much more dynamic offensive team. Thanks in large part to the emergence of Tyreek Hill. He’s only really been a central part of the offense for the 2nd half of the season. Yet he still ranks 11th in the NFL with 11 touchdowns. He’s a threat to take it to the house every time he touches the ball.

Kansas City’s defense has also got better. Terrance Mitchell has really come alive at the corner spot. With teams afraid to throw at Marcus Peters, there’s really not a lot of options for teams in the passing game. It’s unclear if Justin Houston will play, but they didn’t have him in Week 1.

As for the Chargers, they have simply been decimated with injuries. San Diego has 20 players out for the season another 7 listed as questionable and 1 doubtful. The fact that they could only score 17 points against an awful Browns defense really speaks volumes to where they are at right now. That’s now 5 straight games where they have scored 21 or fewer points.

Chiefs are 10-1 ATS in their last 11 road games after the first month of the season. Chargers are 4-13 ATS in their last 17 home games after the first month of the season. San Diego is also 0-8 ATS in their last 8 home games after failing to cover 4 or 5 of their last 6 games.