The Kansas City Chiefs (4-0) host the Indianapolis Colts (2-2) this weekend on Sunday Night Football. Kickoff is set for 8:20 PM EST on October 6th at Arrowhead Stadium and the game will be broadcast on NBC.

Oddsmakers opened this game up with the Chiefs listed as 11-point home favorites. That spread moved down by half a point after early betting, as Kansas City is currently available at -10.5. The total for this matchup is 56.5 points. Click here for a full look at the Week 5 NFL odds and for more links to our individual game previews.

Chiefs vs Colts Game Odds & Betting Preview

Indianapolis Colts

The Colts dropped back to .500 on the season last week after a disappointing 31-24 loss at home to Oakland. Indianapolis fell behind 21-10 in the first half and never fully recovered, coming up just short despite outscoring the Raiders 14-10 over the final two quarters.  QB Jacoby Brissett was 24/46 for 265 yards and three touchdowns while RB Marlon Mack was forced to leave the game early due to a lower body injury. Zach Pascal had a decent outing through the air, hauling in four receptions for 42 yards. Overall, the Colts offense generated just over 300 total yards of offense and scored three touchdowns.

Indianapolis certainly didn’t have a strong showing on defense against the Raiders, giving up over 350 total yards of offense and three touchdowns. The Colts were especially bad against the run, allowing Oakland rushers to combine for almost 200 yards and one touchdown on the ground.

Kansas City Chiefs

The Chiefs survived their second straight fourth quarter scare after an impressive 2-0 start to the year, slipping by Detroit 34-30 on the road to improve to 4-0 overall. Kansas City couldn’t find a way to create any separation on the scoreboard early, as they actually trailed the Lions by a field goal heading into the fourth quarter before getting the job done late. QB Patrick Mahomes wasn’t at his best but still managed to pass for over 300 yards in the victory. RB LeSean McCoy had a fairly strong game on the ground, rushing for 56 yards and a touchdown on 11 carries. TE Travis Kelce led the way for the receiving corps, recording seven catches for 85 yards. As a whole, the Chiefs racked up just under 450 total yards of offense and scored three touchdowns in the close win.

Kansas City struggled defensively in Week 4, giving up well over 450 total yards of offense and three touchdowns. The Chiefs really had a difficult time trying to slow down Detroit QB Matt Stafford, as he went off for 291 yards and three touchdowns through the air.

Free NFL Betting Predictions and Pick: Chiefs -10.5

Indianapolis was on quite the roll prior to their poor outing against Oakland in Week 4, winning two straight games after almost beating the Chargers in overtime at the beginning of September. However, I think the Colts could be in tough on the road here in Week 5, as Kansas City should be really dialed in after back to back victories that were too close for comfort. The Chiefs won both of their first two matchups this season by at least double-digits but haven’t looked nearly as impressive as of late, beating Baltimore and Detroit by just nine combined points. Still, I think the home favorite offers the most value in this particular spot, as I’m not sold that Jacoby Brissett and the rest of the Indianapolis offense will be able to keep pace with Mahomes and Co. due to some key injuries on offense.

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While Marlon Mack and T.Y. Hilton are both likely to play despite being listed as questionable all week, neither player should be even close to 100%. Kansas City also appears to be welcoming back RB Damien Williams this week, who should provide a spark running the ball out of the backfield and in the passing game as well. The Chiefs are 5-2 against the spread over their last seven games overall, and I think that trend will continue in prime-time on Sunday night. I’ll lay the double-digit spread and look for the home favorites to put on another offensive show here in Week 5 – give me Kansas City!