The Indianapolis Colts (4-2) host the Denver Broncos (2-5) this weekend for an all-AFC showdown from Indiana. Kickoff is set for 1:00 PM EST on October 27th at Lucas Oil Stadium and the game will be broadcast on CBS.

Oddsmakers opened this game up with the Colts listed as 5.5-point home favorites. The spread has shifted by a full point after early betting, as Indianapolis is currently available at -4.5. The total for this matchup is 42.5 points. Click here for a full look at the Week 8 NFL odds and for more links to our individual game previews.

Colts vs Broncos Game Odds & Betting Preview

Denver Broncos

The Broncos saw their modest two game winning streak come to an end last week, falling 30-6 at home against Kansas City on Thursday Night Football. Denver trailed 10-6 after the first quarter but fell apart over the next 45 minutes of the game, getting completely shut out on offense the rest of the way. QB Joe Flacco went 21/34 for 213 passing yards through the air while RB Royce Freeman scored the only touchdown of the game for the Broncos on one of his ten carries for just 35 yards. Courtland Sutton led the way for the receiving corps, making six catches for 87 yards. As a whole, the offense gained just under 300 total yards and found the end zone only once in the loss.

Denver was average at best defensively against the Chiefs, giving up almost 300 total yards of offense and two touchdowns. The Broncos defense couldn’t take advantage of an injury to QB Patrick Mahomes, who was forced to leave the game after suffering a dislocated kneecap.

Indianapolis Colts

The Colts have now won four out of their last five games after beating Houston 30-23 at home to move to 4-2 on the season overall. Indianapolis was up 14-9 at the half and held on for the victory down the stretch, outscoring the Texans 16-14 over the final two quarters. QB Jacoby Brissett went 26/39 for 326 yards and four touchdowns through the air, including two strikes to WR Zach Pascal who found the end zone twice and had his first 100+ receiving yard performance of the year. T.Y. Hilton and Eric Ebron also scored touchdowns, while Marlon Mack led the way on the ground with 44 rushing yards on a team-high 18 carries. Overall, the Colts generated just under 400 total yards of offense and scored four touchdowns in a huge AFC South triumph.

Indianapolis had an average outing on the other side of the ball in Week 7, holding the Texans to just two touchdowns despite giving up well over 400 total yards of offense. The Colts really struggled to contain Houston WR DeAndre Hopkins, who torched the secondary for 106 yards and a touchdown on a game-high nine receptions.

Free NFL Betting Predictions and Pick: Colts -4.5

I think that Indianapolis offers pretty decent value in this particular matchup, as there is no doubt that the Colts have clearly been the better team on both sides of the ball so far this season. Denver also traded away Emmanuel Sanders earlier in the week, so it will be interesting to see how the offense looks without their longtime star wideout on the roster. Either way, the Broncos have scored just 42 total points over their last three games combined, which certainly doesn’t bode well for them heading into a tough road game against the first place team in the AFC South.

Click here for more free NFL picks from our experts on staff.

Indianapolis has also owned Denver against the spread as of late, going a rock-solid 8-2 ATS over the last ten meetings between these two teams. The Colts are also 4-1 against the spread in their last five games overall and a very impressive 8-1 outright over their last nine games at Lucas Oil Stadium. On the other side, the Broncos are just 3-8 against the spread in their last 11 games overall and 2-6 ATS over their last eight games against AFC opponents. I’ll happily lay the 4.5 points and roll with the home favorite here in Week 8 – give me Indianapolis to cover!