The Indianapolis Colts (1-1) host the Atlanta Falcons (1-1) in a Week 3 battle between the AFC and NFC South. Kickoff is set for 1:00 PM EST on September 22nd at Lucas Oil Stadium and the game will be broadcast on CBS.

Oddsmakers opened this game up with the Colts listed as 3-point home favorites. That line has come down by a full point after early betting, as Indianapolis is currently available at -2. The total for this matchup is 47 points. Click here for a full look at the Week 3 NFL odds and for more links to our individual game previews.

Colts vs Falcons Game Odds & Betting Preview

Atlanta Falcons

The Falcons managed to get back to .500 in Week 2 after a thrilling 24-20 home victory over Philadelphia on Sunday Night Football. Atlanta was actually playing from behind with just minutes remaining on the clock before Julio Jones scored a huge touchdown on 4th down. Jones had a fantastic outing, hauling in five catches for 106 yards and two touchdowns. QB Matt Ryan also was solid, going 27/43 for 320 yards and three touchdowns. However, he did really struggle with untimely turnovers, throwing three interceptions that almost cost his team the game. The Falcons also had a rough time moving the ball on the ground, as RB Ito Smith led the way with just 32 rushing yards on four carries. As a whole, the offense racked up just under 400 yards of total offense and scored three touchdowns.

Atlanta was actually half decent on the other side of the ball in Week 2, allowing the Eagles to score only two touchdowns on less than 300 yards of total offense. They also forced Carson Wentz to throw two interceptions and held Miles Sanders to just 2.8 yards per carry on a team-high 10 rushing attempts.

Indianapolis Colts

Indianapolis also managed to get back to .500 after a Week 1 loss to the Chargers, bouncing back nicely in a tightly contested divisional game against Tennessee. The Colts led 13-7 at the half but gave up ten unanswered points in the third quarter before coming back in the final fifteen minutes. QB Jacoby Brissett was solid in his second game after replacing Andrew Luck at quarterback, going 17/28 for 146 yards and three touchdowns. Jordan Wilkins and Marlon Mack combined for 131 rushing yards on the ground while WR T.Y. Hilton caught four passes for 43 yards and a touchdown. Overall, Indianapolis gained over 300 total yards of offense and scored three touchdowns against a tough Titans defense.

The Colts defense was very solid in Week 2, holding the Tennessee offense to under 300 total yards and giving up only two touchdowns. However, Titans RB Derrick Henry did have a decent outing on the ground, rushing 15 times for 82 yards and a score.

Free NFL Betting Predictions and Pick: Colts -2

Indianapolis could easily be 2-0 right now if they had managed to find a way to beat the Chargers in overtime to open the season. However, they now return home after two road games in what should be an entertaining clash with Atlanta. The Falcons might have a bit of an emotional letdown after such an exhilarating last-minute victory against Philadelphia. While Julio Jones and Matt Ryan are clearly in sync, the running game has been completely insignificant so far this year which could cause some problems here in Week 3. The Colts defense has been weakest against the run, but it doesn’t appear as if Atlanta’s offensive line has the personal to take advantage of that. With this spread still being less than a field goal, I think the small home favorite offers the most value in this matchup.

Click here for more free NFL picks from our experts on staff.

The Falcons have also not fared well against the spread against Indy as of late, going just 1-5 ATS over their last five meetings. They are also only 3-7 ATS over their last ten games overall. Finally, Atlanta is also a dreadful 0-11 against the spread over their last 11 games against an AFC opponent. If that wasn’t enough already, Indianapolis is a very impressive 6-1 straight up over their last seven games against the Falcons at Lucas Oil Stadium. Even if Jones and Ryan connect for a few big plays through the air, I like the Colts to control the line of scrimmage and give Jacoby Brissett plenty of time to find an open receiver down field. Marlon Mack is also in a good spot here in Week 3 despite battling a lingering injury. I’ll happily lay the two points and roll with the home favorite – give me Indianapolis!