The Indianapolis Colts (2-1) host the Oakland Raiders (1-2) here in Week 4 for an all-AFC clash. Kickoff is set for 1:00 PM EST on September 29th at Lucas Oil Stadium and the game will be broadcast on CBS.

Oddsmakers opened this game up with the Colts listed as 7-point home favorites. That line has moved down by half a point after early betting, as Indianapolis is currently available at -6.5. The total for this matchup is 45.5 points. Click here for a full look at the Week 4 NFL odds and for more links to our individual game previews.

Colts vs Raiders Game Odds & Betting Preview

Oakland Raiders

The Raiders dropped their second consecutive game last weekend, falling 34-14 on the road in Minnesota. Oakland trailed 21-7 at the half and never recovered, getting outscored 13-7 by the Vikings over the final two quarters. QB Derek Carr was 27/34 for 242 yards and two touchdowns but also threw a costly interception. Josh Jacobs had a hard time getting anything going on the ground, rushing for only 44 yards on 10 carries. TE Darren Waller had another big game to lead the way for the receiving corps, hauling in 13 catches for 134 yards. Overall, the Raiders offense gained over 300 total yards and scored just two touchdowns against a tough Minnesota defense.

Oakland had yet another poor outing defensively in Week 3, allowing the Vikings to generate almost 400 total yards of offense and score four touchdowns. The Raiders were torched on the ground by RB Dalvin Cook, as he rushed for 110 yards and a touchdown on only 16 carries.

Indianapolis Colts

The Colts won their second consecutive game last Sunday, narrowly beating Atlanta 27-24 at home to move to 2-1 on the season overall. Indianapolis had a 20-3 lead at halftime and found a way to hang on down the stretch despite getting outscored 21-7 over the final two quarters. QB Jacoby Brissett had an excellent outing, passing for 310 yards and two touchdowns. RB Marlon Mack led the way on the ground, rushing for 74 yards and a touchdown on 16 carries. T.Y. Hilton exploded for 65 yards receiving and a touchdown on eight catches in the first half alone, but was forced to exit the game due to a quadriceps injury. Hilton has already been ruled out for Week 4, so it will be interesting to see if Zach Pascal, Parris Campbell, and Deon Cain can pick up the slack against a bad Raiders secondary.

Indianapolis was pretty average defensively in Week 3, giving up 397 yards of total offense and three touchdowns. The Colts really struggled to contain star wideout Julio Jones, as he racked up eight receptions for 128 yards and a touchdown despite the loss.

Free NFL Betting Predictions and ATS Pick: Colts -6.5

Even though I am a little bit wary of how Indianapolis will perform offensively without T.Y. Hilton in the lineup, I just can’t get behind the Raiders in this matchup. Marlon Mack should have a field day on the ground, as the Vikings torched Oakland last Sunday for well over 200 rushing yards. Jacoby Brissett has also shown some decent chemistry with Zach Pascal and Parris Campbell, so while they will certainly miss Hilton, I can’t imagine a scenario where they don’t score at least 2-3 touchdowns against a defense that has given up 62 points in two weeks. On the other side, the Raiders offense has also really struggled as of late, scoring just 24 points combined over their last two outings.

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It is also important to note that Oakland has now lost back to back games by at least 18 points. Of course, Kansas City and Minnesota are both very solid teams, but Indianapolis shouldn’t be undersold either. The Colts have already shown that they are still a very strong team without Andrew Luck, which means I am happy to lay anything under a full touchdown in this particular spot. Additionally, The Raiders are only 5-10 against the spread over their last 15 games overall, while Indianapolis is an impressive 6-2-1 ATS in their last nine games. I’m taking the home favorites to cover with relative easy on Sunday afternoon – give me the Colts!