The Kansas City Chiefs (1-0) will host the Philadelphia Eagles (1-0) in one of the more intriguing matchups of Week 2. Kickoff is set for 1:00 EST at Arrowhead Stadium and will be televised locally on FOX.

Oddsmakers currently have the Chiefs listed as a 5.5-point home favorite with the total at 47.5 points. This line has jumped quite a bit already, as it opened with KC laying only 4-points. Click here for a full list of Week 2 betting odds and links to game previews.

Eagles vs Chiefs Vegas Betting Predictions & Game Preview

Kansas City pulled off the biggest upset of Week 1, as few were giving them a chance just to make it respectable, let along win the game vs the Patriots. Which was hard to argue against, given the Pats hadn’t lost a home opener in Week 1 under Belichick. The Chiefs pulled away in the 2nd half and won 42-27 as a 8-point dog. The win did come at a price, as KC lost star safety Eric Berry for the season.

Philadelphia had a strong showing as well, winning 30-17 at Washington. While the Eagles were a 2-point favorite in that game, they had lost 5 straight to the Redskins and winning on the road inside the division is no easy task.

These two teams haven’t played since 2013, when Reid made his first appearance as an opposing head coach in Philly. Kansas City won that game 26-16 as a 3-point dog. It will always mean a little more for Reid going against his old team. At the same time, Eagles head coach Doug Pederson has ties to the Chiefs, as he was the OC from 2013-15.

NFL Betting Predictions & Free Pick Against the Spreadl: Chiefs -5.5

I would have love to get KC at -4 when this line opened, but if you like them to win by more than 4, hard to not like them at the dead number of 5.5. I know the media is finally giving this team some love after the big win in New England, but they have a consistent threat in the AFC since Reid took over.

Click on the link for more free NFL betting predictions from our experts on staff.

A lot of people want to point to the injuries the Patriots had to deal with and that playing into the loss. The Chiefs weren’t 100%. They were down a starting corner and their top running back in Spencer Ware. They just had guys step up and deliver. All the hype around Kareem Hunt being the next Jamaal Charles in KC looks to be legit, as he set the rookie RB record for all-purpose yards in his first game with 246.

The other big thing that really has me excited about this team is Alex Smith didn’t just throw 5-yard passes down the field. He let it rip and if defenses have to respect the deep ball, this offense is going to be tough to stop with all the weapons they have.

The loss of Berry is a huge blow to a defense that excels at forcing you into mistakes and holding teams to field goals instead of touchdowns. They won’t be as strong at safety, but they have some guys who are more than capable of stepping in and playing well. The most important thing defensively is Justin Houston looked to be back in the form that had him nearly break the NFL sack record.

As for the Eagles, the win at Washington looks great on paper, but I’m way down on the Redskins this year after losing offensive coordinator Sean McVay. Just look at how different the Rams offense looked in their first game with McVay calling the offense and how bad Washington was. Philadelphia is without their best defensive back as well in Ronald Darby.

Carson Wentz and the offense looked good, but don’t underestimate how hard it is for the top tier QB’s in this league to play well at Arrowhead when the Chiefs are a contender. KC is going to be as loud as ever in their home opener after what this team did in Week 1.

You also have to take into consideration that the Chiefs have had extra time to prepare having played last Thursday and Reid thrives with extra days to break down an opponent. Reid also has a history of taking care of business against his old assistants (8-3 record). I see no choice but to lean towards the Chiefs.