The Philadelphia Eagles (1-1) host the Detroit Lions (1-0-1) in Week 3 for an all-NFC battle from the City of Brotherly Love. Kickoff is set for 1:00 PM EST on September 22nd at Lincoln Financial Field and the game will be broadcast on FOX.

Oddsmakers opened this game up with the Eagles listed as 7-point home favorites. That line has shifted down by half a point after early betting, as Philadelphia is currently available at -6.5. The total for this matchup is 47.5 points. Click here for a full look at the Week 3 NFL odds and for more links to our individual game previews.

Eagles vs Lions Game Odds & Betting Preview

Detroit Lions

The Lions won their first game of the season in Week 2, slipping by the Chargers at home by a score of 13-10. Detroit trailed 10-6 heading into the fourth quarter but scored the final touchdown of the game to pull off the comeback victory. QB Matthew Stafford was fairly average, going 22/30 for 245 yards and two touchdowns but also giving up two interceptions. RB Kerryon Johnson was definitely a factor on the ground, racking up 88 total yards of offense and scoring a lengthy receiving touchdown to get the Lions on the board in the first quarter. WR Kenny Golladay also had a big game, hauling in eight receptions for 117 yards and a touchdown. As a whole, the offense gained over 300 total yards and scored two touchdowns against a tough Los Angeles defense.

The Lions defense played extremely well in Week 2, holding the high-powered Chargers offense to just 10 points on over 400 yards of total offense. However, Detroit did have a tough time trying to slow down Austin Ekeler and Keenan Allen, as the duo combined for well over 225 yards of total offense and a touchdown.

Philadelphia Eagles

Philadelphia was just minutes away from moving to 2-0 on the season when disaster struck on Sunday Night Football in Atlanta, as Julio Jones escaped a tackle on 4th down and scored a lengthy touchdown en route to a 24-20 Falcons win. The Eagles appeared to be well on their way to victory, leading 20-17 before collapsing down the stretch. QB Carson Wentz didn’t play well at all, going just 25/43 for 231 yards and a touchdown while also getting picked off twice. WR Nelson Agholor was the surprise benefactor of injuries to both Alshon Jeffery and DeSean Jackson, making a game-high eight receptions for 107 yards and a touchdown. Jackson has already been ruled out for Week 3 while Jeffery appears to be questionable at best. This means that the Lions will likely see plenty of TE Zach Ertz, as he also had a big showing against the Falcons with eight catches for 72 yards.

The Eagles defense had a second straight rough outing in Week 2, allowing Atlanta to throw for over 300 yards and three touchdowns through the air. Philadelphia seemed powerless to stop Julio Jones, as he made five catches for 106 yards and two touchdowns.

Free NFL Betting Predictions and Pick: OVER 47.5

As it sits right now, I think the spread for this game looks pretty efficient. While I ordinarily wouldn’t mind laying the 6.5 points and rolling with the Eagles at home, I don’t feel comfortable having to guess at how the multiple injuries at both wide receiver and tight end will impact the Philadelphia offense. Even if Alshon Jeffery is able to suit up on Sunday afternoon, there is no doubt that he is nowhere near 100% healthy. On the other side, I still don’t fully trust the Lions away from Ford Field, especially in a hostile environment like Philadelphia. The biggest reason why I think the OVER on 47.5 is the best play in this particular spot is due to the nature of these two offenses – the stars are definitely aligning to make this a pass-first style of game with plenty of clock stoppages.

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The Eagles weakness on defense is clearly their secondary, as both Washington and Atlanta easily surpassed 300 passing yards while scoring several long touchdowns through the air. Similarly, the Lions defense has also struggled a little bit against the pass, as Arizona threw for over 300 yards in Week 1 before Phillip Rivers had 293 passing yards in Week 2. Detroit also has an above average run defense, which should force Philadelphia to air it out with Zach Ertz and Nelson Agholor. With both teams likely throwing the ball downfield early and often, there should be plenty of opportunities for big plays and scoring points. I’ll stay away from the spread and instead take the OVER on 47.5.