The San Francisco 49ers (2-7) are set to host the New York Giants (1-7) in a Monday Night Football showdown between the two teams with the two worst records in the NFC. Kickoff is set for 8:15 EST at Levi’s Stadium and will be televised on ESPN.

Taking a look at the Week 10 NFL odds, the books have the 49ers listed either as a 3-point point favorite with heavy juice or at -3.5. The total for this one is currently at 44 points.

Giants vs 49ers Vegas Game Preview & Betting Odds

New York will be returning from their bye week hoping to turn things around in the second half of their season. First things first will be snapping a 5-game losing streak. Last time out the Giants lost at home to the Redskins 20-13 as a slim-point dog.

San Francisco comes into this one off one of the more surprising performances of the season. The 49ers snapped a 6-game losing streak with a 34-3 win at home over the Raiders on Thursday Night Football. The most impressive thing is it came with underrated quarterback Nick Mullens making his NFL debut.

These two teams also met up in San Francisco in November of last season. The 49ers won that matchup 31-21 as a 3-point home dog and the game went over the posted total of 41.5.

Free Pro Football Pick Against the Spread: 49ers -3

This is one I would likely pass on if it wasn’t the Monday Night game, but as of right now I have to lean with the 49ers and I would pay the extra juice to get them at -3 instead of -3.5. 

Click here for more free NFL picks from our expert handicappers on staff.

I usually like teams coming off a bye, but this isn’t your usually advantage for a team coming off a bye, as the 49ers also have had extra time to prepare having played on Thursday Night Football last week.

The other thing for me is I just trust San Francisco a lot more to show up for this game. I get this is prime time and everyone wants to shine on Monday Night Football, but I think the Giants are a complete mess right now and a lot of it has to do with the play of Eli Manning. If he hadn’t won this franchise two Super Bowls, I don’t think there’s anyway he’s still there starting quarterback.

He’s old, slow and just not that great anymore. I think a lot of the New York players are very frustrated with him at quarterback. Eli’s lack of mobility and an offensive line that isn’t playing well are definitely major factors to why this offense is struggling. Last time out Manning was sacked 7 times by the Redskins. The week before the Falcons had 4 sacks.

Last week the Raiders had to pull Derek Carr because they couldn’t keep the 49ers out of their backfield. San Francisco had 8 sacks on the game and are T-7th with 24 on the season. I get  the 8 sacks were a direct result of Oakland’s lack of effort, but this definitely seems like a Giants team that’s in a very similar start to the Raiders.

The other big thing here for me is just how impressive Nick Mullens was in his NFL debut. He completed 16 of 22 for 262 yards and 3 scores. I know he’s likely not going to play that well against an NFL defense that is actually trying, but he passed the eye test for me and I’m willing to gamble it wasn’t all luck and that he’ll have another big game at home and keep this Cinderella story going. Give me the 49ers -3!