This Saturday the West Virginia Mountaineers (5-3, 3-2 Big 12) will host the No. 15 ranked Iowa State Cyclones (6-2, 4-1 Big 12). Kickoff is set for 3:30 EST at Milan Puskar Stadium in Morgantown and will be televised on ESPN2.

Oddsmakers currently have the Mountaineers listed as a slim 2.5-point home favorite with the total set at 59.5 points. Check out our Week 10 CFB odds page for a full betting schedule and links to our game previews.

Iowa State vs West Virginia Game Odds & Betting Predictions

The Cyclones magical run continued with a 14-7 win at home over the No. 4 TCU as a 7-point underdog. With the victory ISU became the first team since LSU in 2011 to record two wins over a team ranked inside the Top 5 in the same calendar month. They started out October with that 38-31 road win over then No. 3 Oklahoma.

The Mountaineers also hosted a ranked team this past Saturday, expect they didn’t come away with a win. West Virginia fell 39-50 at home to No. 11 Oklahoma State, failing to cover as a 7.5-point underdog.

Last year West Virginia went on the road and laid it on the Cyclones, winning 49-19 as a 7.5-point road favorite. That marked the 3rd straight win in the series by the Mountaineers, all of which have come by 13 or more points.

College Football Betting Predictions & Free Pick: ISU +2.5

I’ve been on the Cyclones each of the last two weeks and would lean towards taking them again. Iowa State has come out of nowhere to take control of the Big 12 and despite the two wins over Oklahoma and TCU, I still don’t think people are buying this team is for real. Those that were on the bandwagon early have been rewarded, as the Cyclones have covered 4 straight and are 7-1 ATS on the season.

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I just love the level of confidence that Iowa State is playing with and the most important thing is they have shown they can take their act on the road. Not only did the take down the Sooners in Norman, they went into Lubbock and put a 31-13 beating on Texas Tech. I also love the fact that the Cyclones will be out for revenge from that ugly loss to close out last season.

At the same time, I don’t think this a great spot for West Virginia. That game at home last week against Oklahoma State was one they were fired up for. Like the rest of the country, I think the Mountaineers players will have a hard time taking ISU as seriously as they should.

The biggest key to the run by Iowa State is the play they are getting out of their defense. Going back to the 2nd half against Oklahoma, where they held the Sooners to just 7 points, they have now allowed 27 points in their 3.5 games and the 7 they gave up last week to TCU came on kickoff return.

West Virginia on the other hand has had their hands full on the defensive side of the ball. The Mountaineers come in 98th in the country, giving up 31.6 ppg and 116th in total defense, allowing 460.2 ypg (rank 100th or worse against both the run and the pass).

I wouldn’t be shocked if the Cyclones defense wasn’t as dominant as it’s been in recent weeks against West Virginia’s high-powered offense, but at the same time, I think ISU is going to have the easier time moving the football. If the defense continues to play like it has, this could get ugly.

Note that head coach Matt Campbell is 8-1 ATS vs strong passing teams (8+ yards/attempt) as the head coach of the Cyclones and West Virginia is just 1-9 ATS under head coach Dana Holgorsen off a conference loss by 10 or more points.