The San Francisco 49ers (11-3) host the Los Angeles Rams (8-6) this weekend for a primetime NFC West showdown from the Bay Area. Kickoff is set for 8:15 PM EST on December 21st at Levi’s Stadium and the game will be televised on the NFL Network.

Oddsmakers opened this game up with the Rams listed as 6-point road underdogs. The spread has increased by a full point after early betting, as Los Angeles is currently available at +7. The total for this matchup is 45 points. Click here for a full look at the Week 16 NFL odds and for more links to our individual game previews.

49ers vs Rams Game Odds & Betting Preview

Los Angeles Rams

The Rams saw their two game winning streak come to an end last weekend, getting crushed 44-21 on the road against Dallas to drop back to 8-6 overall. Los Angeles gave up four touchdowns in the first half and never recovered, coming up well short on the scoreboard as time expired. QB Jared Goff went 33/51 for 284 passing yards and two touchdowns but also got picked off once as well. Todd Gurley couldn’t really get anything going on the ground, rushing for only 20 yards on a team-high 11 carries. TE Tyler Higbee was really the only bright spot on offense, as he hauled in 12 catches for 111 receiving yards. As a whole, the Rams generated just over 300 total yards of offense and found the end zone three times in the blowout loss.

Los Angeles was atrocious defensively against the Cowboys, getting lit up for almost 500 total yards of offense and five touchdowns. The Rams had no answer for Ezekiel Elliott and Tony Pollard on the ground, as the duo combined for 248 rushing yards and three touchdowns.

San Francisco 49ers

The 49ers have now lost two out of their last three games overall after falling 29-22 at home against Atlanta. San Francisco had a 13-10 lead at the start of the fourth quarter but fell apart down the stretch, getting outscored 19-9 over the final 15 minutes of the game. QB Jimmy Garoppolo wasn’t at his best, going 22/34 for 200 passing yards and a touchdown through the air. RB Raheem Mostert led the way on the ground, rushing for 54 yards and a touchdown on a team-high 14 carries. TE George Kittle torched the Falcons secondary, exploding for 134 yards on a game-high 13 receptions. Overall, the 49ers gained just over 300 total yards and found the end zone twice on offense in the defeat.

San Francisco didn’t have a great outing on the other side of the ball against the Falcons, giving up around 300 total yards of offense and three touchdowns. The 49ers couldn’t find a way to slow down Atlanta WR Julio Jones, allowing him to rack up 13 catches for 134 yards and two touchdowns.

Free NFL Betting Predictions and Pick: Rams +7

As long as this spread doesn’t climb back down prior to kickoff, I’m more than happy to take the full touchdown in this particular spot. While I certainly think that San Francisco will find a way to rebound after a shocking upset loss against Atlanta, it is still important to note how many close games that the 49ers have been involved in so far this season. Despite having a very impressive 11-3 record through their first 14 games, four of those victories game by a touchdown or less. Of course, the Rams did come up almost two touchdowns short when these two rivals met back in early October, which means I have no problem at all avoiding this matchup entirely if Los Angeles is only available at +6.5 by game-time on Saturday evening.

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The Rams have fared better against the spread than San Francisco has so far this year, going a very impressive 9-5 ATS through their first 14 outings. Los Angeles is also a rock-solid 5-2 overall against the spread on the road this season, while the 49ers are a mediocre 3-3-1 ATS through seven games at Levi’s Stadium. Finally, the Rams have also had the upper hand against the spread as of late in this rivalry, covering the number in two out of their last three battles against San Francisco. I’ll roll the dice with the free touchdown and the road favorite here in Week 16 in what should be a highly entertaining NFC West showdown. Give me Los Angeles to cover!