The #1 overall Clemson Tigers (4-0) travel to Chapel Hill in Week 5 for an all-ACC showdown against the North Carolina Tar Heels (2-2). Kickoff is set for 3:30 PM EST on Saturday, September 28th at Kenan Memorial Stadium and the game will be televised nationally on ABC.

Taking a look at the Week 5 college football odds, Clemson opened as a massive 25-point road favorite earlier this week. That line has increased by over a full point after early betting, as the Tigers are currently listed at -26.5. The total for the game is sitting at 61 points.

Vegas Betting Preview & Game Odds: North Carolina vs Clemson

Clemson moved to 4-0 on the season overall last weekend, crushing Charlotte 52-10 at home. The Tigers jumped out to 17-0 lead in the first quarter and never looked back, outscoring the 49ers 35-10 the rest of the way. QB Trevor Lawrence didn’t have to do much in limited action, going 7/9 for 94 yards and two touchdowns. Travis Etienne and Lyn-J Dixon both had solid performances on the ground, combining for 119 rushing yards and two touchdowns. WR Joseph Ngata led the way for the receiving corps, recording three receptions for 62 yards and a score. As a whole, Clemson generated over 450 yards of total offense and scored six touchdowns in the victory.

The Tigers were also extremely on the other side of the ball in Week 4, holding Charlotte to only one touchdown on just over 200 total yards of offense. Clemson was extremely strong against the pass, limiting the 49ers to well under 100 passing yards and not giving up a single touchdown through the air.

North Carolina lost their second game in a row last weekend to drop to 2-0 overall, falling 34-31 at home against Appalachian State. The Tar Heels trailed 27-17 at the half and couldn’t manage to claw all the way back despite outscoring the Mountaineers 14-7 over the final thirty minutes of the game. QB Sam Howell was 27/41 for 323 passing yards and three touchdowns, although he did also throw two interceptions. He also added another score on the ground, while RB Javonte Williams averaged 5.9 yards per carry on 16 touches. WR Dazz Newsome also played well, hauling in six catches for 88 yards and a touchdown. Overall, the UNC offense gained well over 450 total yards and scored four touchdowns in a losing cause.

The Tar Heels defense wasn’t at their best against the Mountaineers in Week 4, giving up almost 400 yards of total offense and three touchdowns. North Carolina really got burned by App State RB Darrynton Evans, who rushed for 78 yards and a game-high three touchdowns on the ground.

NCAA Football Betting Predictions & Free Pick: Clemson -26.5

The Tigers have now won their last two games by a combined score of 93-16, which doesn’t leave me overly concerned about their ability to cover this almost four-touchdown spread against a conference rival. North Carolina has not played well at all over the past several weeks after a hot 2-0 start to the season. With consecutive losses to both Wake Forest and Appalachian State, I’m certainly not optimistic about their chances of staying within striking distance of the #1 overall team in the entire nation. Clemson has also really performed well against the spread over their last nine conference games, going 8-1 overall over that span.

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I’m also not that concerned that the Tigers are on the road this weekend, as they are a perfect 7-0 ATS over their last seven games away from Memorial Stadium. While UNC is a solid 9-4 against the spread over their last 13 conference games, they have not responded well to adversity at all, going just 1-4 ATS immediately following a straight up loss. Clemson is clearly the vastly superior team on both sides of the ball, so I’m going to lay the 26.5 points and roll with the big road favorite in this particular spot. Give me the Tigers to cover!