The No. 2 ranked Ohio State Buckeyes will host the No. 5 ranked Oklahoma Sooners in one of the most anticipated games of Week 2. Kickoff is set for 7:30 EST on Saturday at Ohio Stadium and will be televised nationally on ABC.

Taking a look at this week’s schedule and odds, the Buckeyes are currently a 7.5-point favorite with the total at 64.5 points. Note these two teams played last year in Oklahoma, which Ohio State won 45-24 as a 1-point road favorite.

Ohio State vs Oklahoma Vegas Game Odds & Betting Preview

The Buckeyes ended up cruising to a 49-21 win and cover at Indiana as a 20.5-point favorite. However, that wasn’t as lopsided an affair as the final score would indicate. Ohio State actually trailed 20-21 with less than 5 minutes to play in the 4th quarter. That’s when the Hoosiers started to wear down and the Buckeyes went on a 28-0 run to end the game.

The offense finished up with 596 total yards in the win. J.T. Barrett threw for 304 yards and 3 scores, while true freshman J.K. Dobbins rushed for 181 yards on 29 attempts. Barrett also had 61 yards and a score on the ground. In total Ohio State rushed for 292 yards and that was without projected starter Mike Weber.

Any concerns with Oklahoma struggling out of the gate, were quickly put to rest in a 56-7 blowout win at home over UTEP. However, that wasn’t an overly surprising result, as the Sooners went off as 41.5-point favorites. With that said, it could have been worse had they not called off the dogs in the 2nd half.

Like Barrett, Baker Mayfield got his Heisman campaign off to a strong start. He had just 1 incompletion, as he was 19 of 20 for 329 yards and 3 scores. As for the running game, Oklahoma racked up 180 yards and 4 scores on the ground. It was a committee approach, as 3 different players had between 50-55 yards to lead the way.

College Football Free Betting Pick Against the Spread: Ohio State -7.5

This is going to look like a lot of points for matchup that features two Top 5 teams in the country. More times than not the public is going to side with the dog, especially now that the line has jumped from 6.5 to 7.5. Early percentages reflect just that, as close to 60% of the tickets are coming in on the Sooners.

Click here for more free expert college football picks against the spread and total.

Typically I would lean towards Oklahoma given the revenge from last season, but I just don’t trust this Sooners in this spot. I see this a lot like last week’s Week 1 matchup with Florida State and Alabama, where the public was on the Seminoles with a very similar line.

Oklahoma isn’t going to miss Bob Stoops or all those skill players they lost from last year team’s against a school like UTEP. It will show up in a game against the likes of Urban Meyer and Ohio State. Especially in one of the more hostile environments in college football.

The fact that Indiana’s Richard Lagow threw for over 400 yards on this Buckeyes defense is concerning now that they face a big time talent like Mayfield. However, it was almost as if Ohio State was caught off guard by the Hoosiers offense. They were a different team in the 2nd half and will be locked in from the start against a Top 5 opponent at home.

As for the Ohio State offense, they got off to a slow start in their first game under new offensive coordinator Kevin Wilson. Some of that could have been a result of Indiana’s staff knowing Wilson’s scheme and tendencies, as he was the head coach there the year before. I expect the offense to be rolling and it’s pick your poison with the weapons the Buckeyes have. Not to mention the Sooners defense suffered a big blow with the loss of starting corner Jordan Parker.

Let’s also not forget this is a big time statement game for Ohio State. The last time they played a ranked opponent they were shutout 31-0 by Clemson in the semifinals of the playoffs. I think the Buckeyes jump on the Sooners early and pull away for a double-digit win.