The Carolina Panthers (5-5) travel to Louisiana this weekend for an NFC South clash with the New Orleans Saints (8-2). Kickoff is set for 1:00 PM EST on November 24th at the Mercedes-Benz Superdome and the game will be televised on CBS.

Oddsmakers opened this game up with the Saints listed as 10-point home favorites. The spread hasn’t moved at all after early betting, as New Orleans is currently available at -10. The total for this matchup is 45.5 points. Click here for a full look at the Week 12 NFL odds and for more links to our individual game previews.

Saints vs Panthers Game Odds & Betting Preview

Carolina Panthers

The Panthers lost their second straight game last weekend, falling 29-3 at home against Atlanta. Carolina gave up ten unanswered points in the first quarter and never recovered, scoring just a single field goal the entire game. QB Kyle Allen had his worst performance of the season, throwing four interceptions and no touchdown passes. RB Christian McCaffrey continued to churn out yards on the ground, racking up 191 all-purpose yards. D.J. Moore also chipped in, hauling in eight receptions for 95 yards. Overall, the Panthers gained over 400 total yards of offense but failed to find the end zone in the loss.

Carolina was average defensively against the Falcons, surrendering close to 400 total yards of offense and two touchdowns. The Panthers did do a good job shutting down Atlanta on the ground, allowing only 54 net rushing yards.

New Orleans Saints

The Saints put on a show on the road against Tampa Bay last weekend, improving to 8-2 on the season after an impressive 34-17 win. New Orleans scored 13 unanswered points in the first quarter and never looked back, cruising to a double-digit victory over the final 45 minutes of the game. QB Drew Brees went 28/35 for 228 passing yards and three touchdowns through the air while Alvin Kamara rumbled for 122 total yards on the ground. WR Michael Thomas torched a shaky Buccaneers secondary, making eight catches for 114 yards and a touchdown. As a whole, the Saints generated well over 300 total yards of offense and scored three touchdowns.

New Orleans had a pretty solid outing on the other side of the ball in Week 11, giving up 349 total yards of offense and two touchdowns. The Saints were fantastic defending against the run, as Tampa Bay only managed to gain 36 rushing yards.

Free NFL Betting Predictions and Pick: OVER 45.5

This is actually a pretty tough spot, as both the total and the spread look pretty efficient to me overall. While I am at least a little bit tempted by the boatload of points in a divisional game, I just don’t think I can fully get behind the Panthers right now due to their shaky play defensively as of late. Carolina has now given up 124 total points over just their last four games combined, which is obviously very concerning. The Saints offense also really seemed to turn a corner last weekend, as Alvin Kamara had ten receptions to go along with his 13 carries on the ground and led the way for a 30+ point outburst. A 100% healthy Kamara could do some serious damage against a Panthers defense that has surrendered four rushing touchdowns over their last two outings.

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My favorite play from this AFC South clash is probably the OVER on 45.5 total points, as four out of Carolina’s last six games have resulted in the teams combining for at least 50 points. The total has also gone OVER in five straight meetings between these two divisional rivals that occurred at the Mercedes-Benz Superdome. Finally, the OVER has come through in eight out of the last ten meetings between the Panthers and Saints overall. I’m going to avoid both sides against a tough spread in favor of the OVER on 45.5 total points scored in what should be a fast-paced, entertaining matchup.