This Thursday the Arizona Cardinals (4-4) will host the Seattle Seahawks (5-3) in a critical NFC West matchup. Kickoff is set for 8:25 EST at University of Phoenix Stadium and will be televised nationally on NBC.

Oddsmakers currently have the Seattle listed as a 5.5-point road favorite with the total set at 41.5 points. Check out our Week 10 NFL odds page for a full betting schedule and more links to our game previews.

Seahawks vs Cardinals Vegas Game Odds & Betting Preview

Seattle comes into this contest off a surprising 14-17 home loss to the Redskins as a 8-point favorite. Kicker Blair Walsh didn’t do the Seahawks any favors, as he missed 3 field goal attempts. Even with those miscues, Seattle’s defense had a chance to secure the win, but instead let Washington go 70 yards in 4 plays for the game winning touchdown in the final minutes of regulation.

Arizona comes in off a 20-10 win at San Francisco as a slim 2.5-point favorite. The Cardinals led the entire way, thanks to an early 49ers fumble that set them up with 1st and goal, which they were able to put into the end zone. Arizona has alternated wins and losses since they opened the season with a defeat at Detroit and are still right in the thick of things in the NFC West.

Last year these two teams played two very different games that each came right down the wire. The first was a low-scoring defensive battle that ended in a 6-6 tie at Arizona. The second meeting saw 65 combined points, as the Cardinals pulled out a 34-31 road win in at Seattle.

NFL Betting Predictions & Free Pick Against the Spread: Seahawks -5.5

I would have to roll the dice with Seattle in this one, even though the road team is at a big disadvantage in these Thursday night games. One of the reasons that I’m willing to lay the points is the Seahawks have a strong track record in these Thursday games under head coach Pete Carroll, as they are a perfect 7-0 ATS in this spot. Seattle has also been a great team to back when coming off a loss, as they are 8-2 ATS in their last 10 when coming off defeat.

Click here for more free NFL picks against the spread and total for this week’s games.

At the same time, I just don’t trust this Arizona team at all right now. Getting a road win over the 49ers is nothing to get excited about, as San Francisco hasn’t won a game all season. The biggest concern with the Cardinals being the loss of starting quarterback Carson Palmer, who suffered a season-ending injury in their previous game against the Rams, which they lost 0-33.

Drew Stanton went just 5 of 14 in relief of Palmer against LA. While he threw for 200 yards against the 49ers, he completed just 50% of his attempts. The biggest thing that stands out to me in that game against San Francisco, is the offense leaned heavily on Adrian Peterson, who carried it 37 times for 159 yards. That’s great, but you have to wonder just how much AP will have left in the tank on a short week of rest. At the same time, they will be going up against a much better defense in Seattle, who is giving up just 18.6 ppg and will load up the box to try and force Stanton to beat them with his arm.

I also think this Arizona defense could be in for a long day, as they have not fared well against the better teams they have faced. In fact, they have allowed a combined 38 points in 3 games against the 49ers (twice) and Colts. In every other game they have allowed at least 28 points, giving up 30 or more 5 different times.

It’s no secret that Seattle isn’t as good on the road as they are at home, but at the same time the Cardinals are just 5-13 ATS in their last 18 home games. Arizona is also a mere 1-6 in their last 7 off a SU win and 0-7 ATS in their last 7 after allowing less than 15 points. Give me the Seahawks -5.5.