The #16 overall Oregon Ducks (2-1) travel to California this weekend for a Pac-12 showdown against the Stanford Cardinal (1-2). Kickoff is set for 7:00 PM EST on Saturday, September 21st at Stanford Stadium and the game will be televised on ESPN.

Taking a look at the Week 4 college football odds, Oregon opened as a 8.5-point road favorite earlier this week. That line has shifted by two full points after early betting, as the Ducks are currently listed at -10.5. The total for the game is sitting at 58.5 points.

Vegas Betting Preview & Game Odds: Stanford vs Oregon

Oregon improved to 2-1 overall last weekend after an impressive 35-3 victory over Montana. The Ducks offense got off to a quick start in the first quarter, scoring 14 unanswered points before tacking on another touchdown before halftime. QB Justin Hebert had a good game, going 30/42 for 316 yards and five touchdowns. RB Travis Dye couldn’t find the end zone but did manage to break the 100-yard rushing plateau, gaining 101 yards on 17 carries. The receiving duo of Johnny Johnson III and Jacob Breeland turned in a fantastic performance, combining for 125 yards and four touchdowns. As a whole, the Oregon offense gained just over 550 total yards of offense and scored five touchdowns.

The Ducks defense really made things difficult for the Montana offense in Week 3, limiting the Grizzlies to under 250 yards of total offense and just three points. Oregon was especially tough against the run, as Montana gained only eight net rushing yards all game long.

Stanford dropped their second game in a row last weekend, falling 45-27 on the road to #15 overall UCF. The Cardinal fell behind 28-7 in the first quarter and didn’t ever recover, as they trailed by over 30 points at halftime. QB K.J. Costello didn’t have his best game in his return from injury, going just 21/44 for 199 yards and a touchdown. RB Austin Jones turned in a solid performance on the ground, rushing seven times for 65 yards and a touchdown. WR Michael Wilson led the way for the receiving corps, hauling in five passes for 71 yards and a touchdown.

The Cardinal defense obviously had an extremely poor outing in Week 3, getting torched for six touchdowns and over 550 total yards of offense. Stanford especially struggled to defend against the pass, as UCF QB Dillon Gabriel was 22/30 for 347 yards and four touchdowns.

NCAA Football Betting Predictions & Free Pick: Oregon -10.5

While I would have preferred to grab the Ducks at -8.5 when this game originally opened, I think that there might still be a sliver of value on the Oregon side in this matchup. K.J. Costello did not look good in his first game back after suffering a head injury against Northwestern in Week 1. He could be in tough here in Week 4 against a Ducks defense that has only given up nine points over their last two games combined. Oregon has looked extremely solid this year and could easily be a perfect 3-0 overall if they hadn’t choked in the 4th quarter against Auburn and blown a 21-13 lead.

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Stanford has looked shaky at best over their first three games. Of course, their poor record over the first several weeks of the season is at least partially due to a tough schedule – especially playing USC and UCF back to back on the road. However, it certainly doesn’t get any easier for the Cardinal on Saturday. While Costello will likely help the offense get back on track, it doesn’t appear as if the Stanford defense has any hope of slowing down a powerful Oregon offense. The Ducks have scored over 100 points combined over their last two games, while the Cardinal have given up 45 points in both of their last two games. Even if this game stays close for a few quarters, I think the Oregon defense will get a few stops which should allow Hebert and Co. to gain some separation on the scoreboard down the stretch. I’ll take the road favorite to win by double-digits – give me the Ducks!