The Louisville Cardinals (2-7) travel to New York this weekend to take on the #13 overall Syracuse Orange (7-2) in ACC action.  Kickoff is set for 7:00 PM EST at the Carrier Dome and the game will be broadcast on ESPN2.

Taking a look at the Week 11 college football odds, Syracuse opened as a 21-point home favorite earlier this week. That line has barely moved at all after early betting, as the Orange are currently listed at -21.5. The total for the game is sitting at 67.5 points.

Vegas Betting Preview & Game Odds: Syracuse vs Louisville

Louisville dropped to 2-7 on the season last weekend after getting demolished 77-16 by Clemson. The Cardinals got badly outplayed on both sides of the ball, allowing three Tigers to rush for over 100 yards while only mustering 52 yards on the ground themselves. They also trailed by 30+ points by halftime, which had to be devastating for Bobby Petrino. QB Jawon Pass also looked terrible against Clemson, barely reaching 100 yards through the air while also throwing two interceptions. As a whole, Louisville is averaging just 21.6 points per game (117th overall) on 344.7 yards of total offense (112th overall). They have really struggled to move the ball on the ground so far this season, averaging only 112.8 rushing yards per game (119th overall).

The Cardinals have also been one of the worst  defensive teams in the country all season long, as they are giving up an average of 40.8 points per game (124th overall) on 462.8 total yards of offense (115th). They have been awful rush, as they are currently allowing 277.4 yards per game on the ground (127th overall).

Syracuse won their third consecutive game last weekend to move to 7-2 and continue climbing up the AP Top 25. The Orange really brought their A-game against #22 North Carolina State in Week 9 before going on the road in Week 10 and beating Wake Forest 41-24. QB Eric Dungey has really been on a roll as of late, throwing for 411 yards and three touchdowns against the Wolfpack before rushing for over 100 against the Demon Deacons. Syracuse has really started racking up the points over their last several games, as they currently are the #2 overall offense in the entire ACC. As a whole, they are currently averaging 43.3 points per game – 8th overall nationwide.

Things have looked somewhat average on the other side of the ball for the Orange, as they are currently giving up an average of 28.1 points per game (77th overall). However, they have really struggled against the pass through their first nine games, allowing opponents to rack up 267.0 yards per game through the air (111th overall).

NCAA Football Betting Predictions & Free Pick: Syracuse -21.5

Louisville could easily be in for another long game here in Week 11, as the Orange have now scored at least 40 points in three consecutive games. Syracuse almost beat #2 overall Clemson several weeks ago before reeling off three straight wins. The Cardinals are badly outclassed on both sides of the ball in this matchup, and I certainly don’t expect them to be able to keep this game close for more than a couple of quarters. While their defense continues to give up huge statistical outings to their opponents, things have been just as dreadful on offense. I honestly think there could be a 24+ point difference on the scoreboard by the final whistle, so I think the Orange offer a ton of value with this current line.  Click here for more free NCAAF picks from our top rated handicappers.

The Cardinals are just 3-13 ATS over their last 16 games against teams with a winning record. They are also 0-5 ATS over their last five games on the road and 0-4 ATS in their last four games following a loss. Syracuse is 6-2-1 ATS over their last nine games and 5-1-1 ATS in their last seven games on turf. They are also a very solid 8-0-1 ATS in their last nine games after a win.

These two teams are pretty much exact opposites – starting with their mirror 7-2 and 2-7 records. Then you have the fact that Louisville is currently the worst offensive team in the ACC while the Orange are currently trailing only Clemson in terms of offensive output. I really don’t see how this game will be close after halftime, especially considering how demoralized the Cardinals have to be after losing by 60+ last weekend. Throw in the fact that Syracuse is at home this week – where they are a perfect 6-0 – and I’m sold on a relatively easy cover. I’ll lay the three touchdowns and roll with the favorite – give me the Orange.