The New Orleans Saints (11-3) head to Nashville this weekend for an inter-conference clash against the Tennessee Titans (8-6). Kickoff is set for 1:00 PM EST on December 22nd at Nissan Stadium and the game will be televised on FOX.

Oddsmakers opened this game up with the Saints listed as 3-point road favorites. The spread has come down by half a point after early betting, as New Orleans is currently available at -2.5. The total for this matchup is 50.5 points. Click here for a full look at the Week 16 NFL odds and for more links to our individual game previews.

Titans vs Saints Game Odds & Betting Preview

New Orleans Saints

The Saints avoided losing a second straight game by crushing Indianapolis 34-7 at home on Monday Night Football to improve to 11-3 overall. New Orleans jumped out to an early 20-0 lead and never looked back, holding the Colts completely scoreless until the fourth quarter. QB Drew Brees was fantastic, going a ridiculous 29/30 for 307 passing yards and four touchdowns through the air. RB Alvin Kamara averaged almost five yards per carry on the ground while WR Michael Thomas exploded for 128 receiving yards and a touchdown on a game-high 12 catches. Overall, the Saints gained well over 400 total yards of offense and found the end zone four times in the blowout victory.

New Orleans also played extremely well defensively against the Colts, barely surrendering 200 total yards of offense and allowing only a single touchdown. The Saints completely shut down Indianapolis on the ground, limiting them to just 46 rushing yards the entire game.

Tennessee Titans

The Titans saw their four game winning streak come to an end last weekend after falling 24-21 at home against Houston to drop to 8-6 on the season overall. Tennessee trailed 14-0 at the half and couldn’t quite find a way to pull off an impressive comeback despite outscoring the Texans 21-10 over the final two quarters of the game. QB Ryan Tannehill went 22/36 for 279 passing yards and two touchdowns through the air but also got picked off once as well. RB Derrick Henry led the way on the ground, rushing for 86 yards on a team-high 21 carries. A.J. Brown ran circles around the Texans secondary, racking up 114 receiving yards and a touchdown on eight catches. As a whole, the Titans generated well over 400 total yards of offense and scored three touchdowns despite coming up just short on the scoreboard.

Tennessee had a mediocre outing on the other side of the ball against the Texans, giving up close to 400 total yards of offense and three touchdowns. The Titans had no answer for Houston WR DeAndre Hopkins, allowing him to turn just six catches into 119 receiving yards.

Free NFL Betting Predictions and Pick: Saints -2.5

I’m more than happy to lay the 2.5 points and take a red-hot New Orleans squad against the spread in this inter-conference battle. While Tennessee has also been playing pretty well since Ryan Tannehill took over at quarterback, the Titans defense has now given up at least three touchdowns in four out of their last six outings. Tennessee hasn’t exactly been unstoppable against the spread at home this year either, going a pretty mediocre 4-3 ATS through their first seven games at Nissan Stadium. On the other side, the Saints are an extremely impressive 5-1 against the spread through their first six road games. They have also gone a perfect 10-0 outright over their last ten battles against opponents from the AFC conference.

Click here for more free NFL picks from our experts on staff.

While it is also important to note that the Titans seem to have New Orleans number against the spread in recent years, the Saints did grind out an impressive cover during their last trip to Nissan Stadium back in 2011. Tennessee might have a hard time finding the same sense of urgency they had last weekend in what was basically a must-win divisional matchup against Houston. While the Titans are still mathematically alive in the race for the post-season, they certainly are no longer in the drivers seat with their current record of just 8-6. I’ll take a shot with the road favorite here in Week 16 in what should be a very entertaining game filled with plenty of offense – give me New Orleans to cover!