The schedule for the 2018 NFL regular-season was released on Thursday, April 19th. That same night oddsmakers were quick to post the opening lines for Week 1 of the season.

I’ve put together a full betting schedule below. You will find the opening line, current spread and total for each matchup. We will also be posting links to all of our game previews, where our experts will give out a free lean on the spread or total.

Week 1 NFL Vegas Game Lines:  Point Spreads & Betting Totals

The 2018 season will officially get underway on Thursday, September 6th with the defending Super Bowl champion Philadelphia Eagles taking on the Atlanta Falcons. A rematch from last year’s Division Round of the Playoffs, which the Eagles prevailed 15-10. As of right now the Eagles are a slim 2.5-point home favorite.

Looking to Sunday’s card, there’s plenty of intriguing matchups on the card. There are three games that really stand out above the rest to me. The first is a rematch between the Texans and Patriots at Foxboro. These two teams met in Week 3 at New England last year, which many felt was the coming out party for Texans rookie quarterback Deshaun Watson, who threw for 301 yards and 2 scores in a 36-33 upset win. It will be Watson’s first action in a real game since tearing his ACL back in Week 8 of last season. I wasn’t surprised to see New England favored, but it was a bit shocking to see the Pats laying almost a touchdown.

The next game that really has me excited is the 49ers at the Vikings. Minnesota is considered a legit Super Bowl contender and will be debuting new starting quarterback Kirk Cousins against everyone’s favorite breakout team in the 49ers. San Francisco closed out the season with 5 straight wins after starting the season 1-10. It just so happened their 5-0 finish came at the same time that Jimmy Garroppolo was inserted into the lineup. You can see just how much respect the 49ers are getting by the fact that they opened as a mere 4-point dog, but that number has since been bet up to 6.

The final game that gets my attention is the Cowboys at the Panthers. Dallas is looking to rebound after a disappointing 2017 season, while the Panthers are just a couple seasons removed from their Super Bowl run. The oddsmakers see a very evenly matched game, as Carolina is a slim 2.5-point home favorite.

Some other interesting lines out there include the Jaguars currently being listed as a 3-point road favorite over the Giants. Only two other teams are giving points on the road in Week 1.

The biggest favorite on the board is the Saints, who are a giving 9.5 at home to the Buccaneers. The only other team laying more than a touchdown is the Packers, who are a 7.5-point favorite at home against the Bears on Sunday Night Football.

Week 1 concludes as it has for several years now with a double-header on Monday Night Football. The first matchup doesn’t exactly get the juices flowing, as the Jets will visit the Lions. However, the second game will be one to tune into, as the LA Rams visit the Coliseum to take on the Oakland Raiders. The Rams have been the talk of the NFL with all their big additions this offseason and should get quite the test in what will be an electric atmosphere in Oakland for the return debut of head coach Jon Gruden.

For even more expert advice, be sure to check out our free NFL picks page.

Week 1 NFL Odds

Thursday, September 6, 2018

Time (TV)MatchupOpenCurrentTotalPreview
8:30pm (NBC)Atlanta Falcons
Philadelphia Eagles
+4
-4
+2.5
-2.5
45.5Preview

Sunday, September 09, 2018

Time (TV)MatchupOpenCurrentTotalPreview
1:00pm (FOX)Pittsburgh Steelers
Cleveland Browns
-8
+8
-4.5
+4.5
46.5Preview
1:00pm (CBS)Cincinnati Bengals
Indianapolis Colts
+2.5
-2.5
+3
-3
47Preview
1:00pm (CBS)Tennessee Titans
Miami Dolphins
-2.5
+2.5
-1
+1
45Preview
1:00pm (FOX)San Francisco 49ers
Minnesota Vikings
+4.5
-4.5
+6
-6
45.5Preview
1:00pm (FOX)Houston Texans
New England Patriots
+6.5
-6.5
+6
-6
50.5Preview
1:00pm (FOX)Tampa Bay Buccaneers
New Orleans Saints
+7
-7
+9.5
-9.5
49.5Preview
1:00pm (CBS)Jacksonville Jaguars
New York Giants
-3.5
+3.5
-3
+3
43.5Preview
1:00pm (CBS)Buffalo Bills
Baltimore Ravens
+4
-4
+7
-7
40.5Preview
4:05pm (CBS)Kansas City Chiefs
Los Angeles Chargers
+3
-3
+3
-3
47.5Preview
4:25pm (FOX)Seattle Seahawks
Denver Broncos
+1.5
-1.5
+3
-3
42Preview
4:25pm (FOX)Washington Redskins
Arizona Cardinals
+1
-1
PK
PK
44Preview
4:25pm (FOX)Dallas Cowboys
Carolina Panthers
+2.5
-2.5
+2.5
-2.5
42.5Preview
8:20pm (NBC)Chicago Bears
Green Bay Packers
+7.5
-7.5
+7.5
-7.5
47.5Preview

Monday, September 10, 2018

Time (TV)MatchupOpenCurrentTotalPreview
7:10pm (ESPN)New York Jets
Detroit Lions
+6.5
-6.5
+6.5
-6.5
44.5Preview
10:20pm (ESPN)Los Angeles Rams
Oakland Raiders
-4.5
+4.5
-4.5
+4.5
49.5Preview

Check Out Each of the Weekly NFL Odds & Betting Lines: