The schedule for the 2019 NFL regular-season was just released and shortly after oddsmakers set the opening lines for Week 1 of the season.

Week 1 NFL Vegas Game Lines:  Point Spreads & Betting Totals

The 2019 season will officially get underway on Thursday, September 5th. It’s the 100th anniversary season, so they decided to change things up. In years past the defending champ would play at home in the opener. This season it’s a classic NFC rivalry between the Green Bay Packers and Chicago Bears.

The New England Patriots will instead play their first games as defending champs on Sunday Night Football, as they are set to host the Pittsburgh Steelers.

The rest of Sunday’s card leaves a lot to be desired, as there’s just not a lot of great matchups on paper. There are a number of division games that will draw attention, but I would have to think Falcons @ Vikings, Chiefs @ Jaguars, Rams @ Panthers, [email protected] Browns and Colts @ Chargers are the best of the bunch.

Week 1 will conclude with a Monday Night Football double-header. First it will be the Texans @ Saints, followed by the Broncos @ Raiders.

The biggest favorite on the board is the Eagles, who are a 8-point favorite at home against division rival Washington. Seahawks aren’t far behind as a 7.5-point home favorite against the Bengals. You also have the Cowboys (vs NYG) and Saints (vs HOU) as 7-point home favorites.

The big thing to keep in mind with these odds, is a lot can change between now and September. We still are a week away from the NFL Draft. There could be some big trades in the works, plus you are going to have guys emerge and also get hurt in training camp that could completely change the outlook of a team.

For even more expert advice, be sure to check out our free NFL picks page.

Week 1 NFL Odds

Thursday, September 5, 2019

Time (TV)MatchupSpreadTotal
8:30pm (NBC)Green Bay Packers
Chicago Bears
+3.5
-3.5
45.5

Sunday, September 08, 2019

Time (TV)MatchupSpreadTotal
1:00pm (FOX)Atlanta Falcons
Minnesota Vikings
+4.5
-4.5
47.5
1:00pm (CBS)Washington Redskins
Philadelphia Eagles
+8
-8
46
1:00pm (CBS)Buffalo Bills
New York Jets
+3.5
-3.5
38.5
1:00pm (FOX)Baltimore Ravens
Miami Dolphins
-3.5
+3.5
36.5
1:00pm (FOX)San Francisco 49ers
Tampa Bay Buccaneers
+1.5
-1.5
49
1:00pm (FOX)Kansas City Chiefs
Jacksonville Jaguars
-4.5
+4.5
52.5
1:00pm (CBS)Tennessee Titans
Cleveland Browns
+4.5
-4.5
45
1:00pm (CBS)Los Angeles Rams
Carolina Panthers
-3
+3
50.5
4:05pm (CBS)Cincinnati Bengals
Seattle Seahawks
+7.5
-7.5
43.5
4:25pm (FOX)Indianapolis Colts
Los Angeles Chargers
+3
-3
48
4:25pm (FOX)Detroit Lions
Arizona Cardinals
PK
PK
48
4:25pm (FOX)New York Giants
Dallas Cowboys
+7
-7
46
8:20pm (NBC)Pittsburgh Steelers
New England Patriots
+6
-6
51.5

Monday, September 9, 2019

Time (TV)MatchupSpreadTotal
7:10pm (ESPN)Houston Texans
New Orleans Saints
+7
-7
46
10:20pm (ESPN)Denver Broncos
Oakland Raiders
+3
-3
43.5

Check Out Each of the Weekly NFL Odds & Betting Lines: