It’s time to turn our attention to Week 16 of the 2019 NFL regular-season. Hard to believe that there’s just two more weeks left before the playoffs. I’ve put together a betting schedule with the game odds for each matchup.

Our staff will also be previewing each game and giving out a free betting lean on either the spread or total. Links to these previews will be added in the tables below, so be sure to check back often.

Week 16 NFL Vegas Game Lines: Point Spreads & Betting Totals

No more Thursday Night Football, but we get a trio of NFL matchups on Saturday. First up it’s the red-hot Buccaneers hosting the Texans, followed by a huge AFC East clash with the Patriots hosting the Bills and finally the 49ers host the Rams in prime time.

Sunday’s card doesn’t have a ton of great matchups, but there a few that are sure to get people’s attention. The best game in the early slate in a non-conference matchup with the Titans hosting the Saints. In the afternoon it will be all eyes on Eagles hosting the Cowboys, as it’s likely to determine the winner of the NFC East.

We finish things off with the Bears hosting the Chiefs on Sunday Night Football. Last but not least is a massive NFC North showdown with the Vikings hosting the Packers on Monday Night Football.

You can also click on the following link for a full list of the free NFL picks posted by our expert handicappers.

Week 16 NFL Odds (From 5Dimes)
Date/TimeMatchupSpreadTotalPreview
Sat Dec 21st
1:00 PM
Houston Texans
Tampa Bay Buccaneers
-3
3
50.5Preview
Sat Dec 21st
4:30 PM
Buffalo Bills
New England Patriots
6
-6
38.5Preview
Sat Dec 21st
8:15 PM
Los Angeles Rams
San Francisco 49ers
7
-7
45Preview
Sun Dec 22nd
1:00 PM
Jacksonville Jaguars
Atlanta Falcons
7
-7
46Preview
Sun Dec 22nd
1:00 PM
New Orleans Saints
Tennessee Titans
-2.5
2.5
50.5Preview
Sun Dec 22nd
1:00 PM
New York Giants
Washington Redskins
2
-2
41Preview
Sun Dec 22nd
1:00 PM
Pittsburgh Steelers
New York Jets
-3
3
38Preview
Sun Dec 22nd
1:00 PM
Cincinnati Bengals
Miami Dolphins
-1
1
46Preview
Sun Dec 22nd
1:00 PM
Carolina Panthers
Indianapolis Colts
7
-7
46.5Preview
Sun Dec 22nd
1:00 PM
Baltimore Ravens
Cleveland Browns
-9.5
9.5
49Preview
Sun Dec 22nd
4:05 PM
Detroit Lions
Denver Broncos
7
-7
38Preview
Sun Dec 22nd
4:05 PM
Oakland Raiders
Los Angeles Chargers
7
-7
45Preview
Sun Dec 22nd
4:25 PM
Dallas Cowboys
Philadelphia Eagles
-2
2
46Preview
Sun Dec 22nd
4:25 PM
Arizona Cardinals
Seattle Seahawks
9
-9
51Preview
Sun Dec 22nd
8:20 PM
Kansas City Chiefs
Chicago Bears
-6
6
45Preview
Mon Dec 23rd
8:15 PM
Green Bay Packers
Minnesota Vikings
5.5
-5.5
47Preview

Check Out Each of the Weekly NFL Odds & Betting Lines: