Canadian football is not a league that I follow or handicap, so my CFL betting advice is limited. Most online books put out odds on Canadian games. If you do choose to bet on it you will need to make sure the book you choose always has spreads and totals available.
For the most part, you can handle CFL betting like just about any other football league. Be aware of the rule differences and the fact that there does seem to be more of a talent gap than in other leagues. The difference in talent can lead to both larger point spreads and higher totals.
Home field advantage appears to be a bigger factor in CFL betting than some other sports. That doesn’t mean just load up on home teams without thinking about it. It does mean that you should take special notice of how many points a team is getting or giving at home. That will make it easier to find some lines to exploit.