| Anaheim Ducks | Josh Manson | D | Ques Wed – Lower Body | Thu, Oct 7 | Manson is dealing with a lower-body injury, and it is unclear if he will lace up against the Jets in the season opener. |
| Arizona Coyotes | Kyle Capobianco | D | Out Indefinitely – Lower Body | Fri, Oct 8 | Capobianco is out of commission due to a lower-body injury, and it is unclear how long he will be debilitated. |
| Arizona Coyotes | Phil Kessel | RW | Ques Thurs – Foot | Fri, Oct 8 | Kessel is dealing with a foot injury, and it is unknown if he will take on the Blue Jackets on Thursday. |
| Arizona Coyotes | Barrett Hayton | C | Ques Thurs – Lower Body | Fri, Oct 8 | Hayton is bothered by a lower-body ailment, and it remains to be seen if he will take part in the season opener versus the Blue Jackets. |
| Arizona Coyotes | Alex Galchenyuk | C | Out Indefinitely – Upper Body | Fri, Oct 8 | Galchenyuk is idle with an upper-body injury, and he will miss an undetermined length of time. |
| Boston Bruins | Curtis Lazar | C | Out Indefinitely – Upper Body | Fri, Oct 8 | Lazar is idle due to an upper-body injury, and he will miss an undetermined length of time. |
| Buffalo Sabres | Lukas Rousek | RW | Out Indefinitely – Knee | Tue, Sep 14 | Rousek is sidelined after undergoing surgery to repair a torn ACL, and team officials have yet to provide an exact return date. |
| Buffalo Sabres | Jack Eichel | C | Out Indefinitely – Neck | Thu, Sep 23 | Eichel has landed on the injured reserve list due to herniated discs in his neck, and he will miss an undetermined length of time. |
| Buffalo Sabres | John Jason Peterka | RW | Ques Thurs – Lower Body | Fri, Oct 8 | Peterka has a lower-body injury, and it is unclear if he will play in the season opener against the Canadiens. |
| Buffalo Sabres | Rasmus Dahlin | D | Ques Thurs – Lower Body | Sun, Oct 10 | Dahlin is tending to a lower-body injury, and it has yet to be established if he will take on the Canadiens on Thursday. |
| Calgary Flames | Johannes Kinnvall | D | Out Indefinitely – Lower Body | Tue, Sep 21 | Kinnvall is sidelined with a lower-body injury, and it is unclear when he will return to the lineup. |
| Calgary Flames | Connor Zary | C | Out Indefinitely – Ankle | Fri, Sep 24 | Zary is idle with a fractured ankle, and a timetable for return has yet to be established. |
| Calgary Flames | Blake Coleman | C | Elig Oct 18 – Suspension | Fri, Oct 8 | Coleman is serving a two-game suspension for boarding, and he is eligible to return against the Ducks on October 18. |
| Calgary Flames | Brad Richardson | RW | Ques Sat – Lower Body | Sun, Oct 10 | Richardson is dealing with a lower-body injury, and it has yet to be established if he will suit up in the season opener against the Oilers. |
| Carolina Hurricanes | Vincent Trocheck | C | Out Indefinitely – Undisclosed | Sun, Oct 10 | Trocheck has been assigned to the injured reserve list with an unspecified injury, and he will miss an undetermined length of time. |
| Carolina Hurricanes | Jake Gardiner | D | Out For Season – Back | Mon, Sep 6 | Gardiner is sidelined after surgery to repair back and hip injuries, and he will miss the entire 2021-22 season. |
| Chicago Blackhawks | Jonathan Toews | C | Ques Wed – Illness | Thu, Oct 7 | Toews is suffering from chronic immune response syndrome, and it is undetermined if he will be available for Wednesday’s battle versus the Avalanche. |
| Chicago Blackhawks | Wyatt Kalynuk | D | Out Indefinitely – Ankle | Fri, Oct 8 | Kalynuk has been posted to the injured reserve list with a right ankle sprain, and he will miss an undetermined length of time. |
| Chicago Blackhawks | Caleb Jones | D | Late Nov – Wrist | Fri, Oct 8 | Jones is out of commission with a left wrist strain, and he is projected to miss six weeks of action. |
| Colorado Avalanche | Pavel Francouz | G | Early Nov – Lower Body | Fri, Oct 8 | Francouz has been assigned to the injured reserve list with a lower-body injury, and he is expected to miss three to four weeks. |
| Colorado Avalanche | Nazem Kadri | C | Elig Sat – Suspension | Sun, Oct 10 | Kadri has one game remaining on his suspension for an illegal hit to the head, and he is eligible to return Saturday versus the Blues. |
| Colorado Avalanche | Devon Toews | D | Doub Wed – Shoulder | Sun, Oct 10 | Toews is recovering from offseason shoulder surgery, and he is not expected to be active for the season opener against the Blackhawks. |
| Columbus Blue Jackets | Nathan Gerbe | LW | Early Feb – Hip | Sun, Sep 5 | Gerbe is projected to be sidelined for four to six months after undergoing surgery to repair a torn labrum in his left hip. |
| Columbus Blue Jackets | Max Domi | C | Ques Thurs – Shoulder | Fri, Oct 8 | Domi is recovering from surgery to repair a labral tear in his right shoulder, and it remains to be seen if he will face the Coyotes on Thursday. |
| Dallas Stars | Jani Hakanpaa | D | Prob Thurs – Finger | Fri, Oct 8 | Hakanpaa is expected to take the ice for the season opener versus the Rangers despite a fractured pinky finger. |
| Dallas Stars | Ben Bishop | G | Out Indefinitely – Knee | Thu, Sep 30 | Bishop is out of commission after undergoing surgery to repair a torn meniscus, and a timetable for recovery has yet to be established. |
| Detroit Red Wings | Jakub Vrana | LW | Late Jan – Shoulder | Thu, Sep 30 | Vrana is expected to miss at least four months after undergoing shoulder surgery. |
| Edmonton Oilers | Zack Kassian | RW | Ques Wed – Concussion | Fri, Oct 8 | Kassian has been entered in the concussion protocol, and it is uncertain if he will play in the season opener versus the Canucks. |
| Edmonton Oilers | Josh Archibald | RW | Out Indefinitely – Illness | Sun, Oct 3 | Archibald is ailing from myocarditis, and it remains to be seen when he will return to the lineup. |
| Edmonton Oilers | Dylan Holloway | LW | Mid Dec – Wrist | Wed, Sep 15 | Holloway is recovering from offseason wrist surgery, and he is expected to miss at least three months of action. |
| Edmonton Oilers | Dmitri Samorukov | D | Early Nov – Jaw | Mon, Sep 20 | Samorukov has a broken jaw and is expected to miss at least six weeks of action. |
| Edmonton Oilers | Alex Stalock | G | Out For Season – Heart | Thu, Sep 23 | Stalock is likely to sit out the entire 2021-22 season due to a heart condition brought on by a bout with COVID-19. |
| Florida Panthers | Noel Acciari | C | Out Indefinitely – Undisclosed | Thu, Oct 7 | Acciari is sidelined due an undisclosed injury, and he will miss an extended period. |
| Florida Panthers | John Ludvig | D | Ques Thurs – Lower Body | Fri, Oct 8 | Ludvig is battling a lower-body injury, and it has yet to be established if he will face the Penguins on Thursday. |
| Florida Panthers | Sam Bennett | C | Out Indefinitely – Illness | Sat, Oct 9 | Bennett is going through the COVID-19 protocol, and there is no timetable for return. |
| Florida Panthers | Kevin Connauton | D | Late Oct – Lower Body | Sun, Oct 10 | Connauton is out of commission due to a lower-body issue, and he is expected to miss one to two weeks. |
| Los Angeles Kings | Lias Andersson | C | Ques Thurs – Lower Body | Sun, Oct 10 | Andersson is battling a lower-body injury, leaving his availability for Thursday’s contest versus the Golden Knights hazy. |
| Los Angeles Kings | Olli Maatta | D | Ques Thurs – Undisclosed | Sat, Oct 9 | Maata is dealing with an unspecified issue, and it is up in the air if he will take on the Golden Knights in the season opener. |
| Los Angeles Kings | Jonathan Quick | G | Ques Thurs – Shoulder | Fri, Oct 8 | Quick is on the mend from shoulder surgery, and it remains to be seen if he will suit up for Thursday’s matchup versus the Golden Knights. |
| Los Angeles Kings | Quinton Byfield | C | Out Indefinitely – Ankle | Thu, Oct 7 | Byfield suffered a fractured ankle and has landed on the injured reserve list. A timetable for recovery has yet to be established. |
| Minnesota Wild | Matt Boldy | LW | Late Nov – Ankle | Sat, Oct 9 | Boldy is sidelined with a fractured left ankle, and he is expected to miss four to six weeks. |
| Montreal Canadiens | Shea Weber | D | Out For Season – Ankle | Mon, Aug 16 | Weber is expected to miss the entire 2021-22 season with injuries to his ankle, knee and thumb. |
| Montreal Canadiens | Paul Byron | LW | Late Dec – Hip | Mon, Aug 16 | Byron is sidelined after undergoing hip surgery, and he is likely to be out of commission until the end of December. |
| Montreal Canadiens | Sami Niku | D | Out Indefinitely – Concussion | Sat, Oct 2 | Niku is idle with a concussion, and it is unknown how long he will be debilitated. |
| Montreal Canadiens | Joel Edmundson | D | Late Oct – Undisclosed | Thu, Oct 7 | Edmundson is likely to miss two to three weeks due to an unspecified injury. |
| Montreal Canadiens | Cedric Paquette | C | Ques Wed – Lower Body | Thu, Oct 7 | Paquette has a lower-body injury, and it is unknown if he will take part in the season opener versus the Maple Leafs. |
| Montreal Canadiens | Jonathan Drouin | LW | Ques Wed – Illness | Fri, Oct 8 | Drouin is ailing from a non-COVID-19 illness, and it is uncertain if he will be healthy in time for the season opener against the Maple Leafs. |
| Montreal Canadiens | Carey Price | G | Mid Nov – Knee | Fri, Oct 8 | Price is on the mend from off-season knee surgery and has entered the player assistance program. He is expected to be away from the team for at least one month. |
| Montreal Canadiens | Mike Hoffman | LW | Out Indefinitely – Lower Body | Sat, Oct 9 | Hoffman is sidelined due to a lower-body injury, and a timetable for return has yet to be established. |
| New Jersey Devils | Jack Hughes | C | Prob Fri – Undisclosed | Sat, Oct 9 | Hughes is expected to take the ice against the Blackhawks on Friday despite an unspecified injury. |
| New Jersey Devils | Damon Severson | D | Ques Fri – Upper Body | Sat, Oct 9 | Severson is nursing a muscle strain, and it is unknown if he will be available to face the Blackhawks in the season opener. |
| New Jersey Devils | Mackenzie Blackwood | G | Ques Fri – Personal | Sat, Oct 9 | Blackwood has elected to get vaccinated for COVID-19, and his status for the season opener against the Blackhawks is in question. |
| New Jersey Devils | Ty Smith | D | Ques Fri – Undisclosed | Sat, Oct 9 | Smith is tending to an undisclosed issue, and it is unclear if he will be available for Friday’s matchup versus the Blackhawks. |
| New York Islanders | Johnny Boychuk | D | Out Indefinitely – Eye | Thu, Oct 7 | Boychuk will miss an undetermined amount of time due to an eye injury. |
| New York Islanders | Matt Martin | LW | Ques Thurs – Ankle | Fri, Oct 8 | Martin is dealing with an ankle injury, and it is up in the air if he will be active against the Hurricanes on Thursday. |
| New York Islanders | Semyon Varlamov | G | Ques Thurs – Undisclosed | Fri, Oct 8 | Varlamov is bothered by an unspecified issue, and it is unclear if he will lace up against the Hurricanes on Thursday. |
| New York Rangers | Ryan Reaves | RW | Ques Wed – Leg | Thu, Oct 7 | Reaves is bothered by a leg injury, and it is unclear if he will suit up against the Capitals on Wednesday. |
| New York Rangers | Ryan Strome | C | Prob Wed – Hand | Sun, Oct 10 | Strome is dealing with a hand injury, but it is expected that he will suit up for Wednesday’s game versus the Capitals. |
| Ottawa Senators | Ridly Greig | C | Elig Sat – Suspension | Sun, Oct 10 | Greig has been given a one-game suspension for an illegal hit to the head, and he will be eligible to return Saturday versus the Maple Leafs. |
| Ottawa Senators | Colin White | C | Early April – Shoulder | Thu, Oct 7 | White has hit the injured reserve list due to surgery to repair a dislocated shoulder, and he is expected to miss four to six months. |
| Ottawa Senators | Austin Watson | LW | Mid Nov – Ankle | Sun, Oct 10 | Watson is expected to miss four weeks due to an ankle injury. |
| Ottawa Senators | Brady Tkachuk | LW | Out Indefinitely – Holdout | Wed, Sep 22 | Tkachuk is unsatisfied with his current contract, and it remains to be seen when he will report to the team. |
| Ottawa Senators | Angus Crookshank | LW | Late March – Knee | Wed, Sep 22 | Crookshank is sidelined after undergoing knee surgery, and he is expected to miss four to six months. |
| Ottawa Senators | Clark Bishop | C | Out Indefinitely – Ankle | Fri, Oct 1 | Bishop is out of commission with an ankle injury, and he will miss an undetermined length of time. |
| Philadelphia Flyers | Kevin Hayes | C | Late Nov – Abdominal | Tue, Sep 21 | Hayes is out of commission after undergoing abdominal surgery and it is expected to miss six to eight weeks. |
| Philadelphia Flyers | Samuel Morin | D | Late Nov – Knee | Tue, Sep 21 | Morin is idle after undergoing surgery to remove loose bodies from his right knee, and he is expected to miss six to eight weeks of action. |
| Philadelphia Flyers | Cooper Zech | D | Late Nov – Upper Body | Tue, Sep 21 | Zech is projected to miss six to eight weeks with an upper-body injury. |
| Philadelphia Flyers | Tanner Laczynski | C | Out For Season – Hip | Wed, Sep 29 | Laczynski is expected to miss the entire 2021-22 season due to a left hip injury. |
| Philadelphia Flyers | Wade Allison | RW | Out Indefinitely – Ankle | Thu, Oct 7 | Allison is sidelined with a high right ankle sprain, and it is unclear when he will make his season debut. |
| Philadelphia Flyers | Yegor Zamula | D | Ques Fri – Groin | Sun, Oct 10 | Zamula is dealing with injuries to his groin and hip, and it is unknown if he will lace up in the season opener against the Canucks. |
| Pittsburgh Penguins | Sidney Crosby | C | Late Oct – Wrist | Wed, Sep 8 | Crosby is recovering from wrist surgery, and he will remain sidelined until at least the end of October. |
| Pittsburgh Penguins | Jake Guentzel | LW | Out Indefinitely – Illness | Fri, Oct 8 | Guentzel is recovering after contracting the COVID-19 virus, and there is no timetable for return. |
| Pittsburgh Penguins | Zach Aston Reese | LW | Ques Tues – Illness | Sat, Oct 9 | Aston-Reese has been medically cleared after going through the COVID-19 protocols, and it is undetermined if he will lace up against the Lightning on Tuesday. |
| San Jose Sharks | Jeffrey Viel | LW | Ques Sat – Upper Body | Sun, Oct 10 | Viel is bothered by an upper-body injury, and it is undetermined if he will face the Jets on Saturday. |
| San Jose Sharks | Alexander Barabanov | LW | Prob Sat – Lower Body | Sun, Oct 10 | Barabanov is expected to take the ice against the Jets in the season opener despite a lower-body injury. |
| San Jose Sharks | Evander Kane | LW | Out Indefinitely – Poss. Suspension | Thu, Oct 7 | Kane is facing potential discipline from the NHL after allegedly using a fake COVID-19 vaccination card. |
| San Jose Sharks | Nikolai Knyzhov | D | Doub Sat – Abdominal | Sun, Oct 10 | Knyzhov is managing an abdominal issue, and it is unlikely that he will lace up against the Jets on Saturday. |
| Seattle Kraken | Colin Blackwell | C | Ques Tues – Lower Body | Wed, Oct 6 | Blackwell is nursing a lower-body injury, and it is unknown if he will suit up for the season opener versus the Golden Knights. |
| Seattle Kraken | Calle Jarnkrok | C | Out Indefinitely – Illness | Fri, Oct 8 | Jarnkrok is going through the COVID-19 protocol, and a timetable for recovery has yet to be established. |
| Seattle Kraken | Yanni Gourde | C | Mid Nov – Shoulder | Sat, Oct 9 | Gourde is recuperating from offseason shoulder surgery, and he will remain out of commission until sometime in November. |
| St. Louis Blues | Oskar Sundqvist | C | Out Sat – Knee | Sun, Oct 10 | Sundqvist is dealing with a knee injury, and he will not be active for the season opener versus the Avalanche. |
| Tampa Bay Lightning | Cal Foote | D | Mid Nov – Finger | Wed, Sep 22 | Foote is recovering from surgery to repair a tendon in his pinkie finger, and he is not expected to make his season debut until the middle of November. |
| Tampa Bay Lightning | Alex Killorn | LW | Prob Tues – Leg | Wed, Oct 6 | Killorn is recovering from offseason surgery to repair a broken fibula, but is expected to take on the Penguins on Tuesday. |
| Tampa Bay Lightning | Anthony Cirelli | C | Prob Tues – Undisclosed | Sun, Oct 10 | Cirelli is tending to an unspecified issue, but he is likely to face the Penguins on Tuesday. |
| Toronto Maple Leafs | Alex Steeves | C | Out Indefinitely – Shoulder | Wed, Sep 22 | Steeves is sidelined with a shoulder injury, and he will miss an extended period. |
| Toronto Maple Leafs | Auston Matthews | C | Doub Wed – Wrist | Thu, Oct 7 | Matthews is recovering from offseason wrist surgery, and he is not expected to be active against the Canadiens on Wednesday. |
| Toronto Maple Leafs | Ilya Mikheyev | RW | Out Indefinitely – Hand | Sat, Oct 9 | Mikheyev is out of commission with a hand injury, and he is without a definitive timetable for recovery. |
| Vancouver Canucks | Brock Boeser | RW | Prob Wed – Undisclosed | Sun, Oct 10 | Boeser is bothered by an unspecified injury, but it is likely that he will be available Wednesday against the Oilers. |
| Vancouver Canucks | Tyler Motte | C | Doub Wed – Upper Body | Thu, Oct 7 | Motte is dealing with an upper-body injury, and it is unlikely that he will play against the Oilers in the season opener. |
| Vancouver Canucks | Brady Keeper | D | Out Indefinitely – Leg | Mon, Sep 27 | Keeper is sidelined with a broken leg, and he will be unavailable for an unknown amount of time. |
| Vegas Golden Knights | Alex Tuch | RW | Late Jan – Shoulder | Mon, Aug 16 | Tuch is idle after undergoing shoulder surgery, and he is not expected to make his season debut until the latter part of January. |
| Vegas Golden Knights | Shea Theodore | D | Prob Tues – Undisclosed | Wed, Oct 6 | Theodore is expected to take the ice against the Kraken on Tuesday despite an unknown injury. |
| Vegas Golden Knights | Brayden Mcnabb | D | Prob Tues – Leg | Wed, Oct 6 | McNabb is bothered by an upper-leg injury, but he is projected to be available Tuesday versus the Kraken. |
| Vegas Golden Knights | Zach Whitecloud | D | Ques Tues – Lower Body | Sun, Oct 10 | Whitecloud is hampered by a lower-body issue, and it is unclear if he will face the Kraken on Tuesday. |
| Washington Capitals | Nicklas Backstrom | C | Out Indefinitely – Hip | Thu, Sep 23 | Backstrom is sidelined with a hip injury, and team officials have yet to provide an exact return date. |
| Washington Capitals | Dylan Mcilrath | D | Elig Oct 19 – Suspension | Mon, Sep 27 | McIlrath has been handed a two game suspension for an illegal hit to the head, and he is eligible to return October 19 versus the Avalanche. |
| Washington Capitals | Alex Ovechkin | LW | Ques Wed – Leg | Sat, Oct 9 | Ovechkin is managing a left leg injury, leaving his availability for Wednesday’s matchup with the Rangers up in the air. |
| Winnipeg Jets | Dylan Samberg | D | Late Nov – Ankle | Fri, Sep 24 | Samberg is out of commission with a high-ankle sprain, and he is expected to miss six to eight weeks. |
| Winnipeg Jets | Cj Suess | LW | Late Nov – Undisclosed | Tue, Oct 5 | Suess is sidelined with a undisclosed injury, and he is not expected to suit up until late November. |
| Winnipeg Jets | Nikolaj Ehlers | LW | Prob Wed – Upper Body | Sat, Oct 9 | Ehlers is dealing with an upper-body injury, but it is expected that he will dress for Wednesday’s game versus the Ducks. |
| Winnipeg Jets | Mark Scheifele | C | Elig Sat – Suspension | Sun, Oct 10 | Scheifele has one game remaining on his suspension for an illegal hit to the head, and he is eligible to return against the Sharks on Saturday. |