| Arizona Coyotes | Marian Hossa | RW | Out For Season – Illness | Thu, Oct 15 | Hossa has been placed on the long-term injured reserve list with a career-ending skin disorder. |
| Boston Bruins | Brad Marchand | LW | Prob Jan 14 – Hernia | Mon, Jan 4 | Marchand had offseason surgery to fix a sports hernia, but he is expected to face the Devils in the season opener. |
| Boston Bruins | Kevan Miller | D | Out For Season – Knee | Tue, Dec 29 | Miller will miss the entire 2020-21 season after undergoing multiple surgeries to repair a fractured kneecap. |
| Boston Bruins | David Pastrnak | RW | Mid Feb – Hip | Mon, Jan 4 | Pastrnak has been assigned to the injured reserve list until at least the middle of February after having arthroscopic surgery on his right hip and labral repair. |
| Buffalo Sabres | Casey Nelson | D | Out For Season – Personal | Sun, Dec 27 | Nelson has made a personal decision and has opted out of the 2020-21 season. |
| Buffalo Sabres | Zemgus Girgensons | LW | Out Indefinitely – Lower Body | Tue, Jan 5 | Girgensons is sidelined with a lower-body injury, and he will miss an undetermined length of time. |
| Calgary Flames | Josh Leivo | LW | Out Indefinitely – Knee | Mon, Jan 4 | Leivo is on the injured reserve list while recovering from surgery to repair a fractured kneecap, and he will miss an undetermined length of time. |
| Chicago Blackhawks | Andrew Shaw | RW | Prob Jan 13 – Concussion | Thu, Dec 31 | Shaw is managing a concussion, but he is expected to be available for the season opener versus the Lightning. |
| Chicago Blackhawks | Alex Nylander | LW | Out Indefinitely – Knee | Mon, Jan 4 | Nylander has been placed on the injured reserve list while recovering from surgery to repair a meniscus tear in his left knee, and he is expected to be sidelined for four to six months. |
| Chicago Blackhawks | Kirby Dach | C | Late May – Wrist | Mon, Jan 4 | Dach has wound up on the injured reserve list after undergoing surgery to repair a fractured right wrist, and he is expected to miss four to five months. |
| Chicago Blackhawks | Jonathan Toews | C | Out Indefinitely – Illness | Mon, Jan 4 | Toews has been shuttled to the injured reserve list due to an illness, and he is without a definitive timetable for recovery. |
| Chicago Blackhawks | Brent Seabrook | D | Out Indefinitely – Hip | Mon, Jan 4 | Seabrook has been posted to the injured reserve list after undergoing hip surgery, and team officials have yet to provide an exact return date. |
| Columbus Blue Jackets | Brandon Dubinsky | C | Out Indefinitely – Wrist | Mon, Jan 4 | Dubinsky has wound up on the injured reserve list due to a wrist injury and he will miss an extended period. |
| Columbus Blue Jackets | Gustav Nyquist | RW | Early May – Shoulder | Mon, Jan 4 | Nyquist has been assigned to the injured reserve list after undergoing surgery to repair a torn labrum in his left shoulder. He is expected to be sidelined five to six months. |
| Dallas Stars | Ben Bishop | G | Early April – Knee | Mon, Jan 4 | Bishop has been shifted to the injured reserve list is expected to miss five months after having right knee surgery to repair a torn meniscus. |
| Dallas Stars | Anton Khudobin | G | Ques Jan 14 – Personal | Mon, Jan 4 | Khudobin is tending to an immigration issue, and it is unclear if he will be available for the season opener against the Panthers. |
| Dallas Stars | Stephen Johns | D | Out For Season – Concussion | Mon, Jan 4 | Johns will miss the entire 2020-21 season due to post-traumatic headaches and post-concussion syndrome, and he has wound up on the injured reserve list. |
| Dallas Stars | Tyler Seguin | C | Mid March – Hip | Mon, Jan 4 | Seguin has been moved to the injured reserve list after after undergoing surgery to repair a torn labrum in his hip. He is not expected to make his season debut until sometime in March. |
| Edmonton Oilers | Gaetan Haas | C | Prob Jan 13 – Illness | Thu, Dec 31 | Haas was in close contact to a positive COVID-19 case, but is likely to play against the Canucks on Jan 13. |
| Edmonton Oilers | Oscar Klefbom | D | Out For Season – Shoulder | Mon, Jan 4 | Klefbom has been shuttled to the injured reserve list with chronic arthritis in his shoulder, and he will miss the entire 2020-21 season. |
| Minnesota Wild | Mats Zuccarello | RW | Out Indefinitely – Arm | Mon, Jan 4 | Zuccarello has been designated for the injured reserve list while recovering from right arm surgery, and there is no timetable for his return. |
| Minnesota Wild | Alex Stalock | G | Out Indefinitely – Upper Body | Mon, Jan 4 | Stalock is on the injured reserve list with an upper body injury, and he will miss an extended period. |
| New Jersey Devils | Nico Hischier | C | Ques Jan 14 – Leg | Wed, Dec 30 | Hischier is bothered by a leg injury, and it is unknown if he will be available for the season opener versus the Bruins. |
| New York Islanders | Johnny Boychuk | D | Out Indefinitely – Eye | Thu, Dec 31 | Boychuk has been placed on the injured reserve list with optic nerve damage to his eye, and he will be out for the 2020-2021 season. |
| Philadelphia Flyers | Samuel Morin | D | Prob Jan 13 – Knee | Thu, Dec 31 | Morin underwent knee surgery, but he is projected to return to action on January 13th against the Penguins. |
| Philadelphia Flyers | Kirill Ustimenko | G | Out Indefinitely – Hip | Mon, Jan 4 | Ustimenko has been posted to the injured reserve list after undergoing hip surgery, and he is expected to miss four to five months. |
| Pittsburgh Penguins | Zach Aston Reese | LW | Mid Feb – Shoulder | Mon, Jan 4 | Aston-Reese is on the injured reserve list while recuperating from left shoulder surgery, and he is expected to be out of action until at least the middle of February. |
| St. Louis Blues | Vladimir Tarasenko | RW | Early March – Shoulder | Mon, Jan 4 | Tarasenko is expected to be out of commission until at least the beginning of March after having left shoulder surgery, and he has landed on the injured reserve list. |
| Tampa Bay Lightning | Nikita Kucherov | RW | Out For Season – Hip | Mon, Jan 4 | Kucherov will miss the entire regular season due to hip surgery and has been shifted to the injured reserve list. It is undetermined if he will return during the playoffs, should his team make the postseason. |
| Tampa Bay Lightning | Anders Nilsson | G | Out Indefinitely – Concussion | Mon, Jan 4 | Nilsson has been placed on the injured reserve list with a concussion, and he is without a definitive timetable for recovery. |
| Tampa Bay Lightning | Marian Gaborik | RW | Out Indefinitely – Back | Mon, Jan 4 | Gaborik has been posted to the injured reserve list due to a back injury, and there is no timetable for return. |
| Vancouver Canucks | Micheal Ferland | LW | Out Indefinitely – Concussion | Mon, Jan 4 | Ferland has been posted to the injured reserve list due to a concussion, and there is no timetable for return. |
| Washington Capitals | Michal Kempny | D | Early May – Achilles | Mon, Jan 4 | Kempny has been placed on the injured reserve list after undergoing offseason surgery to repair a torn Achilles tendon, and he is expected to miss six to eight months. |
| Washington Capitals | Beck Malenstyn | LW | Early July – Achilles | Mon, Jan 4 | Malenstyn is expected to be sidelined for six to eight months and has been added to the injured reserve list after surgery to repair an Achilles tear. |
| Washington Capitals | Henrik Lundqvist | G | Out For Season – Heart | Mon, Jan 4 | Lundqvist has been designated for the injured reserve list and will not be available for the entire season after recovering from open heart surgery. |
| Winnipeg Jets | David Gustafsson | C | Out Indefinitely – Lower Body | Mon, Jan 4 | Gustafsson has been assigned to the injured reserve list due to a lower-body injury, and he is without a definitive timetable for recovery. |
| Winnipeg Jets | Bryan Little | C | Out For Season – Ear | Mon, Jan 4 | Little has been posted to the injured reserve list while recovering from a perforated eardrum and vertigo symptoms, and he will miss the entire 2020-21 season. |