| Boston Bruins | Charlie Mcavoy | D | Early Dec – Shoulder | Mon, Jun 27 | McAvoy is sidelined until the early part of December, due to a arthroscopic stabilization procedure on his left shoulder. |
| Boston Bruins | Matt Grzelcyk | D | Early Nov – Shoulder | Mon, Jun 27 | Grzelcyk has had right shoulder open stabilization surgery, and it is likely that he will not suit up until early November. |
| Boston Bruins | Brad Marchand | LW | Late Nov – Hip | Mon, Jun 27 | Marchand is recovering from arthroscopy and labral repair surgery in both hips, and it is anticipated that he will not be active until the late part of November. |
| Detroit Red Wings | Robby Fabbri | C | Mid Oct – Knee | Mon, Jun 27 | Fabbri is recovering from ACL surgery, and it has yet to be established if he will be available for the start of the 2022-23 season. |
| Florida Panthers | Anthony Duclair | LW | Mid March – Achilles | Sat, Jul 2 | Duclair is out of commission due to an Achilles tendon injury, and he will be sideline until at least the middle of March. |
| New York Islanders | Cal Clutterbuck | RW | Mid Oct – Shoulder | Mon, Jun 27 | Clutterbuck is recovering from shoulder surgery, but it is anticipated that he will be available for the season opener. |
| Philadelphia Flyers | Ryan Ellis | D | Mid Oct – Pelvis | Thu, Jun 30 | Ellis is sidelined with a pelvic injury, and it is undetermined if he will be available for the season opener. |
| Philadelphia Flyers | Joel Farabee | LW | Mid Oct – Back | Mon, Jun 27 | Farabee is recovering from a disc replacement surgery, and it has yet to be determined if he will suit up for the season opener. |
| San Jose Sharks | Nikolai Knyzhov | D | Mid Oct – Groin | Mon, Jun 27 | Knyzhov is tending to a groin injury and an infection. It has yet to be established if he will be active for the season opener. |
| St. Louis Blues | Alexei Toropchenko | RW | Early Dec – Shoulder | Fri, Jul 1 | Toropchenko is on the mend from offseason shoulder surgery, and he is not expected to make his season debut until the early part of December. |
| Washington Capitals | Alexander Alexeyev | D | Mid Oct – Shoulder | Mon, Jun 27 | Alexeyev is recuperating from left shoulder labral repair surgery, and it has yet to be determined if he will be available for the season opener. |
| Washington Capitals | Nicklas Backstrom | C | Out Indefinitely – Hip | Mon, Jun 27 | Backstrom is sidelined due to left hip surgery, and it is unclear when he will be available to suit up. |
| Washington Capitals | Tom Wilson | RW | Late Jan – Knee | Mon, Jun 27 | Wilson is recovering from left knee ACL surgery, and he will not be available until the middle of January. |